Geary W A, Wooten G F
Brain Res. 1986 Dec 3;399(1):181-4. doi: 10.1016/0006-8993(86)90616-5.
Time-dependent profiles of regional cerebral glucose utilization (RCGU) during morphine withdrawal (MW) were studied by varying the time of 2-deoxy-[14C]glucose (2-DG) administration after a maximal withdrawal-precipitating dose of naloxone was given to morphine-dependent rats. Heterogeneous and multiphasic time-action patterns of RCGU responses were found among 21 brain regions known to exhibit specific elevations in 2-DG labeling during MW. All MW-associated RCGU responses decreased when the interval between naloxone and 2-DG injection approximated the half-life of naloxone in the brain. Of the regions studied, time courses for metabolic responses in the lateral septum and lateral habenula most closely approximated the time course of naloxone availability in the brain. These results suggest that the earliest direct effects of naloxone on central nervous system metabolism in morphine-dependent rats occur in the lateral septum and lateral habenula.
通过改变对吗啡依赖大鼠给予最大剂量诱发戒断的纳洛酮后2-脱氧-[14C]葡萄糖（2-DG）的给药时间，研究了吗啡戒断（MW）期间局部脑葡萄糖利用（RCGU）的时间依赖性变化。在已知MW期间2-DG标记有特异性升高的21个脑区中，发现了RCGU反应的异质性和多相时间作用模式。当纳洛酮与2-DG注射之间的间隔接近纳洛酮在脑中的半衰期时，所有与MW相关的RCGU反应均降低。在所研究的区域中，外侧隔区和外侧缰核的代谢反应时间进程与纳洛酮在脑中的可利用时间进程最为接近。这些结果表明，纳洛酮对吗啡依赖大鼠中枢神经系统代谢的最早直接作用发生在外侧隔区和外侧缰核。
