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大鼠吗啡戒断期间的局部脑葡萄糖利用情况

Regional cerebral glucose utilization during morphine withdrawal in the rat.

作者信息

Wooten G F, DiStefano P, Collins R C

出版信息

Proc Natl Acad Sci U S A. 1982 May;79(10):3360-4. doi: 10.1073/pnas.79.10.3360.

DOI:10.1073/pnas.79.10.3360
PMID:6954484
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC346415/
Abstract

Regional cerebral glucose utilization was studied by 2-deoxy[14C]glucose autoradiography in morphine-dependent rats and during naloxone-induced morphine withdrawal. In morphine-dependent rats, glucose utilization was increased compared with naive controls uniformly (23-54%) in hippocampus, dentate gyrus, and subiculum and reduced in frontal cortex, striatum, anterior ventral thalamus, and medial habenular nucleus. On precipitation of morphine withdrawal by subcutaneous administration of naloxone at 0.5 mg/kg to morphine-dependent rats, glucose utilization was increased in the central nucleus of amygdala (51%), lateral mammillary nucleus (40%), lateral habenular nucleus (39%), medial mammillary nucleus (35%), and medial septal nucleus (35%) (all, P less than 0.01). Significant increases also occurred in several other limbic structures including interpeduncular nucleus, anterior medial and ventral thalamic nuclei, and lateral septal nucleus. Knowledge of the functional cerebral anatomy of the morphine-withdrawal syndrome should facilitate studies directed toward understanding the molecular mechanisms of opiate withdrawal.

摘要

通过2-脱氧[14C]葡萄糖放射自显影术研究了吗啡依赖大鼠及纳洛酮诱导吗啡戒断期间的局部脑葡萄糖利用情况。在吗啡依赖大鼠中，与未用药对照组相比，海马体、齿状回和下托的葡萄糖利用均一致增加（23%-54%），而额叶皮质、纹状体、腹前丘脑和内侧缰核的葡萄糖利用则减少。给吗啡依赖大鼠皮下注射0.5mg/kg纳洛酮诱发吗啡戒断时，杏仁核中央核（51%）、外侧乳头体核（40%）、外侧缰核（39%）、内侧乳头体核（35%）和内侧隔核（35%）的葡萄糖利用增加（均P<0.01）。其他几个边缘结构包括脚间核、前内侧和腹侧丘脑核以及外侧隔核的葡萄糖利用也显著增加。了解吗啡戒断综合征的功能性脑解剖结构应有助于开展旨在理解阿片类药物戒断分子机制的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13f3/346415/d8d212454f78/pnas00449-0306-f.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13f3/346415/d0a936c00ae2/pnas00449-0306-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13f3/346415/65b532dc9ae0/pnas00449-0306-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13f3/346415/16876e2b96c3/pnas00449-0306-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13f3/346415/0069c1a3f6b4/pnas00449-0306-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13f3/346415/68e9f98bb25d/pnas00449-0306-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13f3/346415/d8d212454f78/pnas00449-0306-f.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13f3/346415/d0a936c00ae2/pnas00449-0306-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13f3/346415/65b532dc9ae0/pnas00449-0306-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13f3/346415/16876e2b96c3/pnas00449-0306-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13f3/346415/0069c1a3f6b4/pnas00449-0306-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13f3/346415/68e9f98bb25d/pnas00449-0306-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13f3/346415/d8d212454f78/pnas00449-0306-f.jpg

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