Phifer C B, Browde J A, Hall W G
Brain Res Bull. 1986 Nov;17(5):673-9. doi: 10.1016/0361-9230(86)90199-1.
Rat pups that have been maternally and nutritionally deprived will vigorously ingest diet infused directly into the mouth. The development of nutritive controls in this form of ingestion was examined by administering nutritive and non-nutritive gastric preloads to 6- and 15-day-old pups. In 6 day-old pups, nutritive gastric preloads (0.6 M glucose in distilled H2O or saline) and vehicle preloads were followed by similar intakes; only the change in hydrational state caused by distilled H2O loads appeared to affect intake. By 15 days of age, intake following nutritive preloads was less than intake following non-nutritive preloads. Also, at 15 days, stomach volume at the termination of intake was less following nutritive preloads. In a separate experiment with 6-day-old pups, gastric preloads of an alternative energy source, the ketone beta-hydroxybutyrate, also failed to inhibit intake when given at a dose that did not cause excessive gastric distension. These results indicate that a nutritive control of intake termination in rats is not present at 6 days of age but develops by 15 days of age.
在母体和营养方面受到剥夺的幼鼠会强烈摄取直接注入口腔的食物。通过给6日龄和15日龄的幼鼠给予营养性和非营养性胃预负荷，研究了这种摄取形式中营养控制的发展情况。在6日龄的幼鼠中，营养性胃预负荷（蒸馏水中或生理盐水中的0.6M葡萄糖）和载体预负荷后的摄入量相似；只有蒸馏水负荷引起的水合状态变化似乎会影响摄入量。到15日龄时，营养性预负荷后的摄入量低于非营养性预负荷后的摄入量。此外，在15日龄时，营养性预负荷后摄入结束时的胃容量较小。在另一项针对6日龄幼鼠的实验中，当给予替代能量来源酮体β-羟基丁酸的胃预负荷剂量不会引起过度胃扩张时，也未能抑制摄入量。这些结果表明，大鼠在6日龄时不存在对摄入终止的营养控制，但在15日龄时会发展出来。
