Swithers S E, Hall W G
Department of Psychology, Duke University, Durham, NC 27706.
Physiol Behav. 1989 Nov;46(5):873-9. doi: 10.1016/0031-9384(89)90051-6.
The emergence of controls of independent ingestion in rat pups was studied using nutritive (0.6 M glucose in saline or water) and vehicle gastric preloads. Two hours after preloading, ingestive responses were assessed in a 30-minute test of feeding from the floor. In 6-day-olds, all preloads had similar effects on consumption of a milk diet. In 9-day-olds, however, glucose-water preloads inhibited intake compared to water preloads. This inhibition was secondary to an effect on gastric emptying. Glucose preloads also inhibited intake in 12- and 15-day-olds. Behavioral observations indicated that feeding patterns were altered in response to glucose preloads in 9-day-olds. These results provide evidence for the emergence of a nutritive, postgastric control of independent ingestion between 6 and 9 days of age.
使用营养性（盐溶液或水中的0.6 M葡萄糖）和载体胃预负荷研究了大鼠幼崽独立摄食控制的出现情况。预负荷两小时后，在30分钟的从地面进食测试中评估摄食反应。在6日龄幼崽中，所有预负荷对奶类食物的摄入量有相似影响。然而，在9日龄幼崽中，与水预负荷相比，葡萄糖 - 水预负荷抑制了摄入量。这种抑制是由于对胃排空的影响所致。葡萄糖预负荷在12日龄和15日龄幼崽中也抑制了摄入量。行为观察表明，9日龄幼崽对葡萄糖预负荷的反应是进食模式发生改变。这些结果为6至9日龄之间出现营养性、胃后独立摄食控制提供了证据。
