Quintessence Int. 2024 Jan 23;55(1):52-58. doi: 10.3290/j.qi.b4706089.
The aim of the present study was to investigate whether psoriasis disease constitutes a risk factor for OLP, by assessing the prevalance of psoriasis in a test group with OLP and the control group without.
A cohort of consecutive patients diagnosed clinically and histologically with OLP between 2014 and 2022 was analyzed. The results were contrasted with those obtained in control series matched for age and sex. The correlations between OLP and sex, age, tobacco, alcohol consumption, and psoriasis were assessed using Pearson chi-square test. Multivariate regression analysis was performed to evaluate the association between psoriasis and OLP. For the assessment of the quality of the statistical models, the Akaike information criterion was used.
The study involved 1,016 patients; 738 women (72.6%) and 278 men (27.4%). The average age was 59.38 ± 12.55 years. Of 508 patients with OLP, 16 (3.15%) had comorbid psoriasis, and this was 5 (0.98%) in the control group. Age, sex, smoking, and alcohol habits were not predictive variables in the relationship between psoriasis and OLP in these patients. There were statistically significant differences in relation to the number of locations, with greater extension in patients with OLP and psoriasis (P = .002). According to the multivariate analysis, the odds ratio of OLP for psoriasis was 3.13 (95% CI 1.20-9.68).
This is the first study showing the potential association between psoriasis and OLP, and the results should be considered to improve knowledge of comorbidity of OLP. Based on the results, it is recommended that clinicians collect data regarding history of psoriasis in patients with OLP, and consider possible multiple intraoral locations.
本研究旨在通过评估 OLP 试验组和对照组中银屑病的患病率，来探讨银屑病是否构成 OLP 的风险因素。
对 2014 年至 2022 年间临床和组织学诊断为 OLP 的连续患者队列进行分析。将结果与年龄和性别匹配的对照组结果进行对比。采用皮尔逊卡方检验评估 OLP 与性别、年龄、吸烟、饮酒和银屑病之间的相关性。采用多元回归分析评估银屑病与 OLP 之间的关联。为评估统计模型的质量，使用了赤池信息量准则。
本研究共纳入 1016 名患者，其中 738 名女性（72.6%）和 278 名男性（27.4%）。平均年龄为 59.38 ± 12.55 岁。在 508 名 OLP 患者中，有 16 名（3.15%）患有合并银屑病，而对照组中仅有 5 名（0.98%）。年龄、性别、吸烟和饮酒习惯不是这些患者中银屑病与 OLP 之间关系的预测变量。在与病变部位数量有关的方面存在统计学显著差异，患有 OLP 和银屑病的患者病变部位更多（P =.002）。根据多元分析，患 OLP 的银屑病的比值比为 3.13（95%CI 1.20-9.68）。
这是第一项表明银屑病与 OLP 之间存在潜在关联的研究，这些结果应被视为提高对 OLP 合并症的认识。基于这些结果，建议临床医生在 OLP 患者中收集有关银屑病病史的数据，并考虑可能出现的多个口腔内病变部位。
