口腔扁平苔藓患者血清脂质谱模式的改变：一项横断面研究。
Alterations in serum lipid profile patterns in oral lichen planus: a cross-sectional study.
机构信息
Department of Oral Medicine, Faculty of Medicine and Odontology, University of Murcia, Murcia, Spain.
出版信息
Am J Clin Dermatol. 2012 Dec 1;13(6):399-404. doi: 10.2165/11633600-000000000-00000.
BACKGROUND
Oral lichen planus (OLP) is a chronic inflammatory disorder. Recently, a case-control study found that lichen planus was associated with dyslipidemia in a large series of patients. However, no data were presented about lipid values in patients and controls.
OBJECTIVES
The aim of this study was to investigate the hypothetical association between OLP and dyslipidemia.
MATERIALS AND METHODS
The study included a total of 400 patients (200 with OLP and 200 controls with other oral diseases) and investigated the prevalence of dyslipidemia. The variables analyzed were age, sex, tobacco and alcohol consumption, clinical form of OLP and lipid profiles.
RESULTS
A 54% prevalence of dyslipidemia was found (58% among the OLP group and 50% in the control group). Statistically significant differences in high-density lipoprotein were found between OLP patients and the control group (p = 0.003). A logistic regression model for presence/absence of cardiovascular risk (Castelli's atherogenic index of ≥ 5.1 for men and ≥ 4.5 for women) found statistically significant differences for sex and tobacco consumption.
CONCLUSIONS
The study found a higher atherogenic index amongst OLP patients.
背景
口腔扁平苔藓（OLP）是一种慢性炎症性疾病。最近，一项病例对照研究发现，在大量患者中，扁平苔藓与血脂异常有关。然而，并未报告患者和对照组的血脂值数据。
目的
本研究旨在探讨 OLP 与血脂异常之间的假设关联。
材料和方法
该研究共纳入 400 名患者（200 名 OLP 患者和 200 名患有其他口腔疾病的对照组），并调查了血脂异常的患病率。分析的变量包括年龄、性别、吸烟和饮酒、OLP 的临床形式以及血脂谱。
结果
发现血脂异常的患病率为 54%（OLP 组为 58%，对照组为 50%）。OLP 患者与对照组之间在高密度脂蛋白方面存在统计学显著差异（p=0.003）。用于存在/不存在心血管风险（男性 Castelli 致动脉粥样硬化指数≥5.1，女性≥4.5）的逻辑回归模型发现性别和吸烟对其有统计学显著影响。
结论
该研究发现 OLP 患者的动脉粥样硬化指数更高。
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