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赛拉嗪相关伤口:来自费城一家低门槛伤口护理诊所的临床经验

Xylazine-associated Wounds: Clinical Experience From a Low-barrier Wound Care Clinic in Philadelphia.

作者信息

McFadden Rachel, Wallace-Keeshen Sara, Petrillo Straub Kristi, Hosey Rebecca A, Neuschatz Rachel, McNulty Keara, Thakrar Ashish P

机构信息

From the Prevention Point Philadelphia, Philadelphia, PA (RMF, SW-K, KPS, RH, KMN); Center for Addiction Medicine and Policy (CAMP), University of Pennsylvania, Philadelphia, PA (RMF, APT); Stephen Klein Wellness Center, Project HOME, Philadelphia, PA (SW-K); Leonard A. Lauder Community Care Nurse Practitioner Program, University of Pennsylvania School of Nursing, Philadelphia, PA (RH); Division of Substance Use Prevention and Harm Reduction, Philadelphia Department of Public Health, Philadelphia, PA (RN); and Division of General Internal Medicine, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA (APT).

出版信息

J Addict Med. 2024;18(1):9-12. doi: 10.1097/ADM.0000000000001245. Epub 2023 Nov 29.

DOI:10.1097/ADM.0000000000001245
PMID:38019592
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10967264/
Abstract

The veterinary sedative xylazine is spreading in unregulated opioid supplies across North America. Among people who use drugs with repeated exposure to xylazine, a distinct wound type has emerged. Here, we describe these wounds and share our experience treating them in a nurse-led, low-barrier wound care clinic in Philadelphia, PA. We propose a reimagining of wound treatment across settings to better serve people who use drugs, and we advocate for stronger protections against the harms of an increasingly adulterated drug supply. Our perspective from the epicenter of the xylazine crisis can inform the response of communities across the country who are starting to face harms associated with xylazine.

摘要

兽用镇静剂赛拉嗪正在北美不受监管的阿片类药物供应中蔓延。在反复接触赛拉嗪的吸毒人群中,出现了一种独特的伤口类型。在此,我们描述这些伤口,并分享我们在宾夕法尼亚州费城一家由护士主导的低门槛伤口护理诊所治疗这些伤口的经验。我们提议重新构想各种环境下的伤口治疗,以便更好地服务于吸毒人群,并且我们主张加强保护措施,防止日益掺假的药物供应造成危害。我们从赛拉嗪危机中心得出的观点可以为全国各地开始面临与赛拉嗪相关危害的社区的应对措施提供参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6061/10967264/5cd5fddb4f78/jam-18-9-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6061/10967264/5cd5fddb4f78/jam-18-9-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6061/10967264/5cd5fddb4f78/jam-18-9-g001.jpg

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Clinical Microbiology in Xylazine-Associated Wound Infections.

本文引用的文献

1
Xylazine - Medical and Public Health Imperatives.赛拉嗪——医学与公共卫生的当务之急。
N Engl J Med. 2023 Jun 15;388(24):2209-2212. doi: 10.1056/NEJMp2303120. Epub 2023 Apr 26.
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Safety and preliminary outcomes of short-acting opioid agonist treatment (sOAT) for hospitalized patients with opioid use disorder.阿片类药物使用障碍住院患者短期阿片类激动剂治疗(sOAT)的安全性和初步结果。
Addict Sci Clin Pract. 2023 Feb 24;18(1):13. doi: 10.1186/s13722-023-00368-z.
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Ending Medical Complicity With Skilled-Nursing Facility Discrimination Against People With Opioid Use Disorder.
赛拉嗪相关伤口感染中的临床微生物学
Open Forum Infect Dis. 2025 Aug 7;12(8):ofaf384. doi: 10.1093/ofid/ofaf384. eCollection 2025 Aug.
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"Anything can happen": experiences of people using opioids in a xylazine market.“什么事情都可能发生”:在赛拉嗪市场使用阿片类药物者的经历
Harm Reduct J. 2025 Jul 31;22(1):134. doi: 10.1186/s12954-025-01275-z.
5
Assessing the Real-World Performance of Xylazine Test Strips for Community-Based Drug Checking in Los Angeles.评估用于洛杉矶社区药物检测的赛拉嗪试纸条在现实世界中的性能。
medRxiv. 2025 Jun 30:2025.06.28.25330471. doi: 10.1101/2025.06.28.25330471.
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"It's nothing personal": understanding barriers to relational harm reduction practices during inpatient hospitalization.“这并非针对个人”:理解住院期间减少关系伤害行为的障碍
Harm Reduct J. 2025 Jun 11;22(1):104. doi: 10.1186/s12954-025-01240-w.
7
Community-based drug checking at syringe service programs in New York City observe an increasing prevalence of xylazine from 2021 through 2024.纽约市注射器服务项目中基于社区的药物检测发现,从2021年到2024年,赛拉嗪的流行率呈上升趋势。
Harm Reduct J. 2025 Jun 7;22(1):99. doi: 10.1186/s12954-025-01237-5.
8
Multidisciplinary Guidance to Care for Persons With Xylazine-Associated Wounds.对赛拉嗪相关伤口患者护理的多学科指导。
Open Forum Infect Dis. 2025 May 15;12(6):ofaf299. doi: 10.1093/ofid/ofaf299. eCollection 2025 Jun.
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Scaling up low barrier wound care for people who use drugs: a mixed methods study.扩大针对吸毒者的低门槛伤口护理服务:一项混合方法研究。
Harm Reduct J. 2025 May 21;22(1):84. doi: 10.1186/s12954-025-01241-9.
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Tranq burn: Exploring the etiology of xylazine-related soft tissue injuries.镇静剂灼伤:探索赛拉嗪相关软组织损伤的病因
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Addiction. 2023 Jun;118(6):994-997. doi: 10.1111/add.16124. Epub 2023 Jan 20.
5
Xylazine-Induced Skin Ulcers in a Person Who Injects Drugs in Philadelphia, Pennsylvania, USA.美国宾夕法尼亚州费城一名注射毒品者出现的赛拉嗪所致皮肤溃疡
Cureus. 2022 Aug 19;14(8):e28160. doi: 10.7759/cureus.28160. eCollection 2022 Aug.
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Acute pain and self-directed discharge among hospitalized patients with opioid-related diagnoses: a cohort study.住院的阿片类药物相关诊断患者中的急性疼痛和自我导向出院:一项队列研究。
Harm Reduct J. 2021 Dec 16;18(1):131. doi: 10.1186/s12954-021-00581-6.
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Soc Sci Med. 2020 Sep;260:113183. doi: 10.1016/j.socscimed.2020.113183. Epub 2020 Jul 9.
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Adv Skin Wound Care. 2016 May;29(5):205-15. doi: 10.1097/01.ASW.0000482354.01988.b4.
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Xylazine intoxication in humans and its importance as an emerging adulterant in abused drugs: A comprehensive review of the literature.人类赛拉嗪中毒及其作为滥用药物中新兴掺杂物的重要性:文献综述
Forensic Sci Int. 2014 Jul;240:1-8. doi: 10.1016/j.forsciint.2014.03.015. Epub 2014 Mar 26.