接种疫苗的肾移植受者中 SARS-CoV-2 刺突抗体的表位作图显示与健康对照相比，刺突覆盖率较差。
Epitope Mapping of SARS-CoV-2 Spike Antibodies in Vaccinated Kidney Transplant Recipients Reveals Poor Spike Coverage Compared to Healthy Controls.
机构信息
Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Institute for Cell Engineering, Division of Immunology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
出版信息
J Infect Dis. 2024 May 15;229(5):1366-1371. doi: 10.1093/infdis/jiad534.
Kidney transplant recipients (KTRs) develop decreased antibody titers to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination compared to healthy controls (HCs), but whether KTRs generate antibodies against key epitopes associated with neutralization is unknown. Plasma from 78 KTRs from a clinical trial of third doses of SARS-CoV-2 vaccines and 12 HCs underwent phage display immunoprecipitation and sequencing (PhIP-Seq) to map antibody responses against SARS-CoV-2. KTRs had lower antibody reactivity to SARS-CoV-2 than HCs, but KTRs and HCs recognized similar epitopes associated with neutralization. Thus, epitope gaps in antibody breadth of KTRs are unlikely responsible for decreased efficacy of SARS-CoV-2 vaccines in this immunosuppressed population. Clinical Trials Registration. NCT04969263.
肾移植受者（KTR）接种严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）疫苗后，抗体滴度较健康对照（HC）下降，但 KTR 是否产生与中和相关的关键表位的抗体尚不清楚。来自 SARS-CoV-2 疫苗第三剂临床试验的 78 名 KTR 和 12 名 HC 的血浆进行噬菌体展示免疫沉淀和测序（PhIP-Seq），以绘制针对 SARS-CoV-2 的抗体反应图谱。KTR 对 SARS-CoV-2 的抗体反应性低于 HC，但 KTR 和 HC 识别与中和相关的相似表位。因此，KTR 抗体广度的表位差距不太可能导致 SARS-CoV-2 疫苗在该免疫抑制人群中的疗效降低。临床试验注册。NCT04969263。
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