Cash J, Fehir K M, Pollack M S
Cancer. 1987 Feb 15;59(4):798-800. doi: 10.1002/1097-0142(19870215)59:4<798::aid-cncr2820590423>3.0.co;2-b.
Two patients with early stage chronic lymphocytic leukemia were found to have meningeal involvement. The diagnosis was confirmed by cerebral spinal fluid cytology in the first patient and by flow cytometric analysis in the second patient. Both patients responded well to intrathecal chemotherapy and cranial irradiation. Central nervous system infiltration by tumor cells has rarely been described in chronic lymphocytic leukemia but must be considered in all patients regardless of stage who present with lethargy, dementia, or focal neurologic signs.
两名早期慢性淋巴细胞白血病患者被发现有脑膜受累。第一例患者通过脑脊液细胞学检查确诊，第二例患者通过流式细胞术分析确诊。两名患者对鞘内化疗和头颅照射反应良好。肿瘤细胞浸润中枢神经系统在慢性淋巴细胞白血病中鲜有报道，但对于所有出现嗜睡、痴呆或局灶性神经体征的患者，无论处于何阶段，均须考虑这种情况。
