一名难治性贫血伴原始细胞过多转化患者中t(8;21)易位的一种产物的重复。
Duplication of one of the products of the t(8;21) translocation in a patient with refractory anemia with excess blasts in transformation.
作者信息
Czepulkowski B, Gibbons B, Tucker J, Amess J, Lister T A
出版信息
Cancer Genet Cytogenet. 1987 Mar;25(1):175-7. doi: 10.1016/0165-4608(87)90174-9.
PMID:3802052
Abstract
A 34-year-old man with refractory anemia with excess blasts in transformation is reported, having a t(8;21) translocation and a duplication of one of the products, der(21). The duplicated product had not been observed at presentation in malignant disease, as far as we are aware; thus, the findings are discussed with regard to this case and other possible smoldering leukemias. The diagnostic use of cytogenetics is also considered.
摘要
报告了一名34岁患有转化型伴过多原始细胞难治性贫血的男性，其存在t(8;21)易位以及其中一个产物der(21)的重复。据我们所知，在恶性疾病初诊时未观察到这种重复产物；因此，针对该病例及其他可能的冒烟型白血病对这些发现进行了讨论。还考虑了细胞遗传学在诊断中的应用。
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