前庭康复训练联合抗眩晕药物对前庭神经炎患者眩晕及平衡功能的影响：一项系统评价与Meta分析

Effects of vestibular rehabilitation training combined with anti-vertigo drugs on vertigo and balance function in patients with vestibular neuronitis: a systematic review and meta-analysis.

作者信息

Chen Jia, Liu Zhixiang, Xie Yulong, Jin Song

机构信息

School of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Rehabilitation Department, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.

出版信息

Front Neurol. 2023 Nov 9;14:1278307. doi: 10.3389/fneur.2023.1278307. eCollection 2023.

DOI:10.3389/fneur.2023.1278307

PMID:38020604

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10666171/

Abstract

OBJECTIVE

To investigate the effects of vestibular rehabilitation training (VRT) combined with anti-vertigo drugs on vertigo and balance function in patients with vestibular neuronitis (VN).

DATA SOURCES

PubMed, EMBASE, The Cochrane Library, Web of Science, CNKI, Wan Fang Data, VIP, and CBM were searched until July 13, 2023.

PARTICIPANTS

Patients with vestibular neuronitis participated in the study.

RESULTS

Twenty one studies including 1,415 patients were included in this review for meta-analysis. According to the Physiotherapy Evidence Database (PEDro) quality assessment, four studies received high quality (≥seven scores) and 17 studies received moderate quality (six scores). The meta-analysis showed that VRT combined with anti-vertigo drugs significantly reduced the Dizziness Handicap Inventory (DHI) score, the Vestibular Disorders Activities of Daily Living Scale (VADL) score and the Canal Paresis (CP) score, and improved the overall efficiency and the Berg Balance Scale (BBS) score, promoting vestibular evoked myogenic potentials (VEMPs) returned to normal in VN compared to simple anti-vertigo drugs or VRT alone.

CONCLUSION

The results of this meta-analysis demonstrate the efficacy and safety of VRT combined with anti-vertigo drugs in patients with VN. Combined therapy can alleviate vestibular dysfunction such as vertigo and vomiting in patients, improve daily activity ability and balance ability, in addition to VRT has fewer adverse reactions, so it is extremely safe. However, there are shortcomings such as lack of long-term follow-up and different frequency and duration of treatment. Therefore, future randomized controlled trials (RCTs) with larger sample sizes and longer-term observations are needed to verify the effectiveness of VRT in combination with anti-vertigo drugs for VN.: https://www.crd.york.ac.uk/prospero/.

摘要

目的

探讨前庭康复训练（VRT）联合抗眩晕药物对前庭神经炎（VN）患者眩晕及平衡功能的影响。

资料来源

检索了PubMed、EMBASE、Cochrane图书馆、Web of Science、中国知网、万方数据、维普资讯和中国生物医学文献数据库，检索截至2023年7月13日。

研究对象

前庭神经炎患者参与本研究。

结果

本综述纳入21项研究，共1415例患者进行荟萃分析。根据物理治疗证据数据库（PEDro）质量评估，4项研究质量高（≥7分），17项研究质量中等（6分）。荟萃分析表明，与单纯使用抗眩晕药物或单独进行VRT相比，VRT联合抗眩晕药物可显著降低头晕残障量表（DHI）评分、前庭疾病日常生活活动量表（VADL）评分和半规管轻瘫（CP）评分，提高总体有效率和伯格平衡量表（BBS）评分，促进VN患者的前庭诱发肌源性电位（VEMP）恢复正常。

结论

本荟萃分析结果证明了VRT联合抗眩晕药物治疗VN患者的有效性和安全性。联合治疗可缓解患者眩晕、呕吐等前庭功能障碍，提高日常活动能力和平衡能力，此外VRT不良反应较少，安全性极高。然而，存在缺乏长期随访以及治疗频率和疗程不同等缺点。因此，未来需要更大样本量和长期观察的随机对照试验（RCT）来验证VRT联合抗眩晕药物治疗VN的有效性。：https://www.crd.york.ac.uk/prospero/