Agger-Nielsen Helle Elisabeth, Grøndberg Thomas Stig, Berg-Beckhoff Gabriele, Ovesen Therese
Department of Otorhinolaryngology, Hospital of Southwest Jutland Esbjerg, Esbjerg, Denmark.
Department of Regional Health Research, University of Southern Denmark, Odense, Denmark.
Front Neurol. 2024 May 30;15:1396891. doi: 10.3389/fneur.2024.1396891. eCollection 2024.
This study aimed to investigate the impact of early vestibular rehabilitation training combined with corticosteroids initiated within 2 weeks, compared with corticosteroid treatment, after the peripheral acute vestibular syndrome (pAVS) onset.
PubMed, CINAHL, EMBASE, and SCOPUS. From inception to January 24, 2024. The International Prospective Register of Systematic Reviews approved this study (CRD42023422308).
Five studies involving 235 patients were included in this systematic review and meta-analysis. The subjective outcome measure Dizziness Handicap Inventory (DHI) was pooled for a meta-analysis and was statistically significantly in favor of early vestibular rehabilitation training (early VRT) plus corticosteroids compared with corticosteroids alone: at one-month follow-up ( = 0.00) and 12 months follow-up ( = 0.01). DHI was a critical outcome for measuring the differences in effect of early VRT. The objective outcome measures of caloric lateralization, cervical vestibular-evoked myogenic potentials, and posturography were gathered for a narrative synthesis.
This meta-analysis showed that early VRT in combination with corticosteroids was more effective for treating pAVS than corticosteroid treatment alone. No adverse effects were reported for early VRT.
本研究旨在探讨外周急性前庭综合征（pAVS）发病后2周内开始的早期前庭康复训练联合皮质类固醇与皮质类固醇治疗相比的影响。
PubMed、CINAHL、EMBASE和SCOPUS。从创刊到2024年1月24日。国际前瞻性系统评价注册库批准了本研究（CRD42023422308）。
五项涉及235例患者的研究纳入了本系统评价和荟萃分析。对主观结局指标头晕残障量表（DHI）进行荟萃分析，结果显示，与单独使用皮质类固醇相比，早期前庭康复训练（早期VRT）联合皮质类固醇在统计学上具有显著优势：在1个月随访时（P = 0.00）和12个月随访时（P = 0.01）。DHI是衡量早期VRT效果差异的关键结局指标。对冷热试验侧向化、颈前庭诱发肌源性电位和姿势描记术等客观结局指标进行了叙述性综合分析。
本荟萃分析表明，早期VRT联合皮质类固醇治疗pAVS比单独使用皮质类固醇治疗更有效。未报告早期VRT有不良反应。
