Lavoie E J, Braley J, Rice J E, Rivenson A
Cancer Lett. 1987 Jan;34(1):15-20. doi: 10.1016/0304-3835(87)90068-1.
The tumorigenic activity of benzo[b]fluoranthene, benzo[j]fluoranthene, benzo[k]fluoranthene, and indeno-[1,2,3-cd]pyrene was evaluated in newborn CD-1 mice. The total doses of these non-alternant polycyclic aromatic hydrocarbons employed in this study ranged from 0.5 to 2.1 mumol per mouse. The results of this assay indicate that both benzo[b]fluoranthene and benzo[j]fluoranthene exhibit significant tumorigenic activity. In contrast to these results, neither benzo[k]fluoranthene nor indeno[1,2,3-cd]pyrene were tumorigenic under these assay conditions.
在新生CD-1小鼠中评估了苯并[b]荧蒽、苯并[j]荧蒽、苯并[k]荧蒽和茚并[1,2,3-cd]芘的致瘤活性。本研究中使用的这些非交替多环芳烃的总剂量为每只小鼠0.5至2.1微摩尔。该试验结果表明，苯并[b]荧蒽和苯并[j]荧蒽均表现出显著的致瘤活性。与这些结果相反，在这些试验条件下，苯并[k]荧蒽和茚并[1,2,3-cd]芘均无致瘤性。
