Rice J E, Hosted T J, Lavoie E J
Cancer Lett. 1984 Oct;24(3):327-33. doi: 10.1016/0304-3835(84)90030-2.
Fluoranthene and pyrene are potent cocarcinogens when applied together with benzo[a]pyrene (BaP) on mouse skin. In this study the effect of fluoranthene, pyrene and phenanthrene on the formation of BaP--DNA adducts in mouse skin was investigated. Co-application of either fluoranthene or pyrene with [3H]BaP resulted in an average increase in the level of [3H]BaP--DNA adducts of 56% to 66%, respectively, as compared to [3H]BaP alone. Only minor differences were observed in the ratio of (+/-)anti- to (+/-)synbenzo[a]pyrene diol epoxide--DNA adducts between experimental groups. An average 17% decrease in the formation of [3H]BaP--DNA adducts was observed upon co-application of [3H]BaP on mouse skin with phenanthrene. These data suggest a correlation between the observed increase in tumorigenicity of BaP in the presence of either fluoranthene or pyrene and an increase in the formation of (+/-)anti-benzo[a]pyrene diol epoxide--DNA adducts.
荧蒽和芘与苯并[a]芘（BaP）一起应用于小鼠皮肤时是强效的辅助致癌物。在本研究中，研究了荧蒽、芘和菲对小鼠皮肤中BaP-DNA加合物形成的影响。与单独使用[3H]BaP相比，荧蒽或芘与[3H]BaP共同应用分别导致[3H]BaP-DNA加合物水平平均增加56%至66%。实验组之间（±）反式与（±）顺式苯并[a]芘二醇环氧化物-DNA加合物的比例仅观察到微小差异。当[3H]BaP与菲共同应用于小鼠皮肤时，观察到[3H]BaP-DNA加合物的形成平均减少17%。这些数据表明，在荧蒽或芘存在下观察到的BaP致瘤性增加与（±）反式苯并[a]芘二醇环氧化物-DNA加合物形成增加之间存在相关性。
