Chang Soo-Eun, Below Jennifer E, Chow Ho Ming, Guenther Frank H, Hampton Wray Amanda M, Jackson Eric S, Max Ludo, Neef Nicole E, SheikhBahaei Shahriar, Shekim Lana, Tichenor Seth E, Walsh Bridget, Watkins Kate E, Yaruss J Scott, Bernstein Ratner Nan
Department of Psychiatry, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.
Department of Communication Disorders, Ewha Womans University, Seoul, South Korea.
Neurobiol Lang (Camb). 2025 Apr 2;6. doi: 10.1162/nol_a_00162. eCollection 2025.
Our understanding of the neurobiological bases of stuttering remains limited, hampering development of effective treatments that are informed by basic science. Stuttering affects more than 5% of all preschool-age children and remains chronic in approximately 1% of adults worldwide. As a condition that affects a most fundamental human ability to engage in fluid and spontaneous verbal communication, stuttering can have substantial psychosocial, occupational, and educational impacts on those who are affected. This article summarizes invited talks and breakout sessions that were held in June 2023 as part of a 2-day workshop sponsored by the US National Institute on Deafness and Other Communication Disorders. The workshop encompassed topics including neurobiology, genetics, speech motor control, cognitive, social, and emotional impacts, and intervention. Updates on current research in these areas were summarized by each speaker, and critical gaps and priorities for future research were raised, and then discussed by participants. Research talks were followed by smaller, moderated breakout sessions intended to elicit diverse perspectives, including on the matter of defining therapeutic targets for stuttering. A major concern that emerged following participant discussion was whether priorities for treatment in older children and adults should focus on targeting core speech symptoms of stuttering, or on embracing effective communication regardless of whether the speaker exhibits overt stuttering. This article concludes with accumulated convergent points endorsed by most attendees on research and clinical priorities that may lead to breakthroughs with substantial potential to contribute to bettering the lives of those living with this complex speech disorder.
我们对口吃的神经生物学基础的理解仍然有限,这阻碍了基于基础科学的有效治疗方法的开发。口吃影响着超过5%的学龄前儿童,在全球约1%的成年人中呈慢性状态。作为一种影响人类进行流畅和自然言语交流这一最基本能力的疾病,口吃会对患者的心理社会、职业和教育产生重大影响。本文总结了2023年6月举行的特邀演讲和分组讨论会议,这些会议是由美国国立耳聋及其他交流障碍研究所主办的为期两天的研讨会的一部分。该研讨会涵盖了神经生物学、遗传学、言语运动控制、认知、社会和情感影响以及干预等主题。每位演讲者总结了这些领域当前研究的最新情况,提出了未来研究的关键差距和优先事项,然后由参与者进行了讨论。研究演讲之后是规模较小、有主持人引导的分组讨论会议,旨在引发不同的观点,包括关于口吃治疗靶点定义的问题。参与者讨论后出现的一个主要问题是,大龄儿童和成人的治疗重点应该是针对口吃的核心言语症状,还是无论说话者是否表现出明显的口吃都要注重有效的沟通。本文最后总结了大多数与会者认可的关于研究和临床优先事项的共识点,这些共识点可能会带来突破,极有可能改善患有这种复杂言语障碍者的生活。