Bai Jie, Wei Jia-Quan, Tian Qian, Xue Fen, Zhang Wen, He Hong
Department of Psychiatry, Xi'an Gaoxin Hospital, Xi'an, China.
Front Behav Neurosci. 2023 Nov 16;17:1292835. doi: 10.3389/fnbeh.2023.1292835. eCollection 2023.
Electroacupuncture (EA) is a beneficial physiotherapy approach for addressing neuropsychiatric disorders. Nevertheless, the impact of EA on the gut microbiome in relation to anxiety disorders remains poorly understood.
To address this gap, we conducted a study using a chronic restraint stress (CRS) mouse model to investigate the anti-anxiety outcome of EA and its influence on gut microbiota. Our research involved behavioral tests and comprehensive sequencing of full-length 16S rRNA microbiomes.
Our findings revealed that CRS led to significant anxiety-like behaviors and an imbalance in the gut microbiota. Specifically, we identified 13 species that exhibited changes associated with anxiety-like behaviors. Furthermore, EA partially alleviated both behaviors related to anxiety and the dysbiosis induced by CRS.
In summary, this study sheds light on the alterations in gut microbiota species resulting from CRS treatment and brings new light into the connection between EA's anti-anxiety effects and the gut microbiota.
电针是治疗神经精神疾病的一种有益的物理治疗方法。然而，电针对焦虑症患者肠道微生物群的影响仍知之甚少。
为填补这一空白，我们使用慢性束缚应激（CRS）小鼠模型进行了一项研究，以调查电针的抗焦虑效果及其对肠道微生物群的影响。我们的研究包括行为测试和全长16S rRNA微生物群的综合测序。
我们的研究结果表明，CRS导致了明显的焦虑样行为和肠道微生物群失衡。具体来说，我们鉴定出13种与焦虑样行为相关的变化物种。此外，电针部分缓解了与焦虑相关的行为以及CRS诱导的生态失调。
总之，本研究揭示了CRS治疗导致的肠道微生物群物种变化，并为电针的抗焦虑作用与肠道微生物群之间的联系带来了新的启示。
