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电针对天枢（ST25）和足三里（ST36）的刺激通过调节肠道微生物群和促肾上腺皮质释放因子缓解应激诱导的小鼠肠易激综合征。

Electroacupuncture at Tianshu (ST25) and Zusanli (ST36) alleviates stress-induced irritable bowel syndrome in mice by modulating gut microbiota and corticotropin-releasing factor.

机构信息

Department of Acupuncture and Rehabilitation, the Affiliated Hospital of Nanjing University of Chinese Meidicne, Nanjing 210023, China.

Department of Acupuncture and Rehabilitation, Jiangsu Province Hospital of Chinese Medicine, Nanjing 210029, China.

出版信息

J Tradit Chin Med. 2022 Oct;42(5):732-740. doi: 10.19852/j.cnki.jtcm.20220719.001.

DOI:10.19852/j.cnki.jtcm.20220719.001
PMID:36083480
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9924689/
Abstract

OBJECTIVE: To investigate whether electroacupuncture (EA) at bilateral Tianshu (ST25) and Zusanli (ST36) acupoints could alleviate stress-induced irritable bowel syndrome (IBS) and evaluate its effect on gut microbiota and corticotropin-releasing factor (CRF). METHODS: Thirty C57BL/6 mice were randomly divided into the normal, water avoidance stress (WAS), and WAS+EA groups (10 mice per group). An experimental model of IBS was established by exposing the animals to WAS. The mice were treated with EA at the bilateral Tianshu (ST25) and Zusanli (ST36) acupoints. The abdominal withdrawal reflex test was conducted to evaluate visceral sensitivity in IBS. Gut microbiota was analyzed using 16S rRNA sequencing and analysis. The expression of CRF was determined using immune-ofluorescence and quantitative real-time polymerase chain reaction. RESULTS: EA alleviated visceral hypersensitivity in a mouse model of WAS-induced IBS. It modulated the dysbiosis of gut microbiota induced by WAS. Moreover, it suppressed the WAS-induced overexpression of CRF in colon tissues. CONCLUSION: The findings of this study suggest that EA alleviated WAS-induced IBS mechanisms possibly involving the modulation of the dysbiosis of gut microbiota and suppression of CRF expression.

摘要

目的：研究电针对双侧天枢（ST25）和足三里（ST36）穴位的刺激是否能缓解应激诱导的肠易激综合征（IBS），并评估其对肠道微生物群和促肾上腺皮质释放因子（CRF）的影响。

方法：将 30 只 C57BL/6 小鼠随机分为正常组、水回避应激（WAS）组和 WAS+EA 组（每组 10 只）。通过对动物进行 WAS 暴露建立 IBS 实验模型。对小鼠进行双侧天枢（ST25）和足三里（ST36）穴位的电针治疗。采用腹壁退缩反射试验评估 IBS 患者的内脏敏感性。通过 16S rRNA 测序和分析检测肠道微生物群。采用免疫荧光和实时定量聚合酶链反应检测 CRF 的表达。

结果：电针对 WAS 诱导的 IBS 小鼠模型的内脏高敏感有缓解作用。它调节了 WAS 诱导的肠道微生物群失调。此外，它抑制了 WAS 诱导的结肠组织中 CRF 的过度表达。

结论：本研究结果提示，电针可能通过调节肠道微生物群失调和抑制 CRF 表达缓解 WAS 诱导的 IBS 机制。

相似文献

[1]
Electroacupuncture at Tianshu (ST25) and Zusanli (ST36) alleviates stress-induced irritable bowel syndrome in mice by modulating gut microbiota and corticotropin-releasing factor.

J Tradit Chin Med. 2022-10

[2]
Electroacupuncture Relieves Irritable Bowel Syndrome by Regulating IL-18 and Gut Microbial Dysbiosis in a Trinitrobenzene Sulfonic Acid-Induced Post-Inflammatory Animal Model.

Am J Chin Med. 2020-1-10

[3]
Mechanisms of Peitu Yimu acupuncture in repairing intestinal mucosal barrier by regulating CRF/CRFR1 pathway in diarrhea-predominant irritable bowel syndrome rats.

Zhen Ci Yan Jiu. 2024-5-25

[4]
Electroacupuncture alleviates water avoidance stress-induced irritable bowel syndrome in mice by improving intestinal barrier functions and suppressing the expression of inflammatory cytokines.

J Tradit Chin Med. 2023-6

[5]
[Effect of electroacupuncture at "Zusanli" (ST36) and "Tianshu" (ST25) on intestinal function and autonomic nerve balance in rats with irritable bowel syndrome].

Zhen Ci Yan Jiu. 2023-2-25

[6]
Regulatory role of electroacupuncture on satellite glial cell activity in the colon and dorsal root ganglion of rats with irritable bowel syndrome.

J Tradit Chin Med. 2024-10

[7]
[Study on the mechanism of electroacupuncture repairing intestinal barrier via regulating mast cell in rats with diarrhea-predominant irritable bowel syndrome].

Zhen Ci Yan Jiu. 2023-3-25

[8]
[Involvement of Pirt /TRPV1 signaling in acupuncture-induced reduction of visceral hypersensitivity in diarrhea-predominant irritable bowel syndrome rats].

Zhen Ci Yan Jiu. 2021-4-25

[9]
[Effect of electroacupuncture of "Hegu" (LI4) and "Zusanli" (ST36) on intestinal sensitivity and motility in irritable bowel syndrome rats].

Zhen Ci Yan Jiu. 2020-4-25

[10]
[Comparison of effects of electroacupuncture at "Tianshu" (ST25) and "Dachangshu" (BL25) on intestinal sensitivity and expression of muscarinic MR and 5-HTR in irritable bowel syndrome rats].

Zhen Ci Yan Jiu. 2019-4-25

引用本文的文献

[1]
Microbiota-gut-brain-axis: a new target of acupuncture therapy for post-stroke cognitive impairment.

Front Microbiol. 2025-4-24

[2]
Research on the mechanism of core acupoints in electroacupuncture for functional constipation based on data mining and network acupuncture.

Front Med (Lausanne). 2024-12-11

[3]
Acupuncture and moxibustion intervention in functional dyspepsia: Gastric and duodenal regulation.

Heliyon. 2024-8-6

[4]
Acupuncture influences multiple diseases by regulating gut microbiota.

Front Cell Infect Microbiol. 2024

[5]
Electroacupuncture intervention alleviates depressive-like behaviors and regulates gut microbiome in a mouse model of depression.

Heliyon. 2024-4-22

[6]
The combination of gut microbiota-depleted treatment and fecal microbiota transplantation is an important strategy to verify the efficacy of Traditional Chinese Medicine though modulation of gut dysbiosis.

J Tradit Chin Med. 2024-2

[7]
Cardiovascular implications of inflammatory bowel disease: An updated review.

World J Cardiol. 2023-11-26

[8]
Acupuncture as multi-targeted therapy for the multifactorial disease obesity: a complex neuro-endocrine-immune interplay.

Front Endocrinol (Lausanne). 2023

[9]
The efficacy and neural mechanism of acupuncture therapy in the treatment of visceral hypersensitivity in irritable bowel syndrome.

Front Neurosci. 2023-9-4

本文引用的文献

[1]
"Adjusting Internal Organs and Dredging Channel" Electroacupuncture Ameliorates Insulin Resistance in Type 2 Diabetes Mellitus by Regulating the Intestinal Flora and Inhibiting Inflammation.

Diabetes Metab Syndr Obes. 2021-6-9

[2]
Improvement of intestinal flora: accompany with the antihypertensive effect of electroacupuncture on stage 1 hypertension.

Chin Med. 2021-1-7

[3]
Electroacupuncture relieves irritable bowel syndrome by increasing expression of nucleotide-binding oligomerization domain protein-like receptor family pyrin domain containing 6 in water-avoidance stress mice.

J Tradit Chin Med. 2020-6

[4]
Electroacupuncture Relieves Irritable Bowel Syndrome by Regulating IL-18 and Gut Microbial Dysbiosis in a Trinitrobenzene Sulfonic Acid-Induced Post-Inflammatory Animal Model.

Am J Chin Med. 2020-1-10

[5]
Electroacupuncture Regulates Disorders of Gut-Brain Interaction by Decreasing Corticotropin-Releasing Factor in a Rat Model of IBS.

Gastroenterol Res Pract. 2019-10-13

[6]
The influence of the brain-gut axis in inflammatory bowel disease and possible implications for treatment.

Lancet Gastroenterol Hepatol. 2019-5-20

[7]
[Electroacupuncture of "Tianshu" (ST 25) Suppresses Visceral Pain Possibly by Down-regulating Mast Cell Activation, and Tryptase and SP Expression in Rats with Post-infectious Irritable Bowel Syndrome].

Zhen Ci Yan Jiu. 2018-7-25

[8]
Rebuilding the Gut Microbiota Ecosystem.

Int J Environ Res Public Health. 2018-8-7

[9]
Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R and Lactobacillus rhamnosus CLR2 improve quality-of-life and IBS symptoms: a double-blind, randomised, placebo-controlled study.

Benef Microbes. 2018-6-11

[10]
Fecal and Mucosa-Associated Intestinal Microbiota in Patients with Diarrhea-Predominant Irritable Bowel Syndrome.

Dig Dis Sci. 2018-5-17

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