Jing Yongfa, Chen Lingling, Geng Linna, Shan Zhaofei, Yang Juling
Handan First Hospital Handan City Hebei Province China.
Nutrition Department of Handan First Hospital Handan City Hebei Province China.
Health Sci Rep. 2023 Nov 29;6(12):e1737. doi: 10.1002/hsr2.1737. eCollection 2023 Dec.
The community acquired pneumonia (CAP) is a common disease with high incidence rate and mortality among the elderly. This study aims to explore the association between vitamins, cytokines, and CAP infected by different pathogens in Handan First Hospital.
The subjects of this study were elderly patients with community-acquired pneumonia in Handan First Hospital and healthy elderly people in the community from February 2018 to December 2019. The study include 234 CAP patients and 180 healthy elderly people. The differences between the healthy and CAP groups were analyzed by blood routine test, urine routine test, Liquid chromatography tandem mass spectrometry (LC-MS/MS) detection of vitamin level, and Enzyme linked immunosorbent assay (ELISA) detection of cytokine level. Sputum culture was used to detect pathogens.
According to our results, there was no significant difference in the contents of vitamin A, vitamin D, vitamin E, and vitamin C in serum between the healthy and CAP elderly. However, compared with the control group, the levels of serum cytokines of IL-2, IL-17, and TGF-β in the CAP patients were significantly increased. In addition, IL-17 was positively correlated with white blood cells, neutrophils, platelet/lymphocyte ratio and neutrophil/lymphocyte ratio of CAP patients, and negatively correlated with lymphocytes. The four pathogens with the highest positive rates were , , and . In patients with infection, the IL-2, IL-17, and TGF-β levels were significantly higher than the levels in the control group; IL-17 was also significantly increased in the serum of patients infected with , , and .
There is no direct association between vitamins in serum and community acquired pneumonia (CAP). However, the cytokines are closely related to the clinical indicators and pathogens of CAP patients, which can provide references for the diagnosis, prognosis and treatment of CAP patients.
社区获得性肺炎（CAP）是一种常见疾病，在老年人中发病率和死亡率较高。本研究旨在探讨邯郸市第一医院维生素、细胞因子与不同病原体感染的CAP之间的关联。
本研究的对象为2018年2月至2019年12月在邯郸市第一医院就诊的老年社区获得性肺炎患者和社区健康老年人。研究包括234例CAP患者和180例健康老年人。通过血常规、尿常规、液相色谱串联质谱（LC-MS/MS）检测维生素水平以及酶联免疫吸附测定（ELISA）检测细胞因子水平，分析健康组与CAP组之间的差异。采用痰培养检测病原体。
根据我们的结果，健康老年人和CAP老年人血清中维生素A、维生素D、维生素E和维生素C的含量无显著差异。然而，与对照组相比，CAP患者血清中IL-2、IL-17和TGF-β细胞因子水平显著升高。此外，IL-17与CAP患者的白细胞、中性粒细胞、血小板/淋巴细胞比值和中性粒细胞/淋巴细胞比值呈正相关，与淋巴细胞呈负相关。阳性率最高的四种病原体分别是 、 、 和 。在 感染患者中，IL-2、IL-17和TGF-β水平显著高于对照组；在感染 、 和 的患者血清中，IL-17也显著升高。
血清维生素与社区获得性肺炎（CAP）之间无直接关联。然而，细胞因子与CAP患者的临床指标和病原体密切相关，可为CAP患者的诊断、预后和治疗提供参考。
