Conway Jade, Lipner Shari R
School of Medicine, New York Medical College, Valhalla, NY, USA.
Department of Dermatology, Weill Cornell Medicine, New York, NY, USA.
SAGE Open Med Case Rep. 2023 Nov 29;11:2050313X231213149. doi: 10.1177/2050313X231213149. eCollection 2023.
Overall, 80%-90% of patients with psoriasis will have nail involvement at some point during their lifetime, and nail changes, on average, are more common in patients with longer disease duration. Since there is accelerated keratinocyte proliferation and cell turnover in cutaneous psoriasis plaques compared to normal skin, it has been hypothesized that psoriasis increases nail growth rate. We describe a case of a 44-year-old male with a 10-year history of cutaneous and nail psoriasis, with acceleration in nail growth rate for 2 years prior to presentation. Clinical examination of the fingernails showed very long nails with onychorrhexis, onycholysis, and koilonychia and scattered erythematous plaques involving the chest and arms. We report a case of rapid fingernail growth in a patient with a 10-year history of psoriasis with skin and nail manifestations. Our case supports the hypothesis that increased cell turnover in psoriasis patients affects nail growth rate.
总体而言,80% - 90%的银屑病患者在其一生中的某个阶段会出现指甲受累情况,平均而言,指甲改变在病程较长的患者中更为常见。由于与正常皮肤相比,皮肤银屑病斑块中的角质形成细胞增殖加速且细胞更新加快,因此有人推测银屑病会提高指甲生长速度。我们描述了一例44岁男性患者,有10年皮肤和指甲银屑病病史,在就诊前2年指甲生长速度加快。手指甲的临床检查显示指甲非常长,伴有甲纵裂、甲剥离和匙状甲,胸部和手臂有散在的红斑斑块。我们报告了一例有10年银屑病病史且有皮肤和指甲表现的患者指甲快速生长的病例。我们的病例支持了银屑病患者细胞更新增加会影响指甲生长速度这一假说。