Aiempanakit Kumpol, Geater Alan, Limtong Preeyachat, Nicoletti Kathleen
Division of Dermatology, Department of Internal Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
Int J Dermatol. 2017 Jul;56(7):788-791. doi: 10.1111/ijd.13620. Epub 2017 Apr 23.
Linear nail growth rate is affected by various conditions, one of which is the level of blood flow. Our supposition was that topical minoxidil, which has vasodilatory properties, can increase the rate of nail growth. The aim of this study was to determine the impact of topical minoxidil on nail growth. A 5% topical minoxidil solution was applied twice daily to the fingernails of 32 participants. Two groups of 16 participants were randomly chosen. In one group, the applications were made to the right index and left ring fingernails, and, in the other, the left index and right ring fingernails. During each visit (weekly during the first month and every 2 weeks during the second month), the nail length of six fingernails (index, middle, and ring of both hands) was measured using a digital caliper. Beginning in the first week, the mean nail length of the treated nails was greater than that of nails in the untreated group with statistical significance. There were no systemic or cutaneous side effects. During the first month, the mean growth of the treated nails was 4.27 mm/month compared with 3.91 mm/month in the untreated nails (P = 0.003). These findings suggest that a 5% concentration of topical minoxidil can stimulate nail growth with increased growth beginning in the first week of application. The results may have important implications for the treatment of nail disorders; however, a comparable study involving participants with nail disorders is highly recommended.
指甲线性生长速度受多种因素影响，其中之一是血流量水平。我们推测具有血管舒张特性的外用米诺地尔可提高指甲生长速度。本研究的目的是确定外用米诺地尔对指甲生长的影响。对32名参与者的指甲每日两次涂抹5%的外用米诺地尔溶液。随机选取两组，每组16名参与者。一组涂抹于右手食指和左手无名指指甲，另一组涂抹于左手食指和右手无名指指甲。在每次就诊时（第一个月每周一次，第二个月每两周一次），使用数字卡尺测量六根手指（双手的食指、中指和无名指）的指甲长度。从第一周开始，治疗组指甲的平均长度大于未治疗组，具有统计学意义。未出现全身或皮肤副作用。在第一个月，治疗组指甲的平均生长速度为4.27毫米/月，未治疗组为3.91毫米/月（P = 0.003）。这些发现表明，5%浓度的外用米诺地尔可刺激指甲生长，在涂抹的第一周即可使生长加快。该结果可能对指甲疾病的治疗具有重要意义；然而，强烈建议开展一项涉及指甲疾病患者的对照研究。
