Kageura M, Kataoka M, Hara K, Nagata T
Forensic Sci Int. 1986 Dec;32(4):229-35. doi: 10.1016/0379-0738(86)90199-4.
During a forensic toxicological GC/MS screening, changed compounds of hydroxyzine were found in a man's urine taken about 20 h after ingesting sake (Japanese liquor) and tranquilizers. The structures of those compounds were assigned to 4-chlorodiphenylmethane(I), p-chlorbenzophenone(III), norchlorcyclizine(IV), 7-(p-chloro-alpha-phenylbenzyl)-2-hydroxy-2H,3H-oxazolo-[3,2 -alpha] piperazine(V), 1-(p-chloro-alpha-phenylbenzyl)-4-methylpiperazine-3-one(VI), N-(p-chloro-alpha-phenylbenzyl)-N'-formylmethyl-N'- hydroxyethyl-1,2-ethenediamine(VII) and 1-(p-chloro-alpha-phenylbenzyl)-4-[2-ethoxy(2-ethoxy)-ethyl] piperazine(VIII) on the basis of the fragmentation patterns and relative retention times except VIII which was identified using the synthesized compound. I, V, VI, VII and VIII have not been reported previously, but the possibility of metabolites of hydroxyzine is still uncertain.
在一次法医毒理学气相色谱/质谱筛查中，在一名男子摄入清酒（日本酒）和镇静剂约20小时后采集的尿液中发现了羟嗪的变化化合物。根据碎片模式和相对保留时间，这些化合物的结构被确定为4-氯二苯甲烷（I）、对氯二苯甲酮（III）、去氯环嗪（IV）、7-（对氯-α-苯基苄基）-2-羟基-2H，3H-恶唑并-[3,2-α]哌嗪（V）、1-（对氯-α-苯基苄基）-4-甲基哌嗪-3-酮（VI）、N-（对氯-α-苯基苄基）-N'-甲酰甲基-N'-羟乙基-1,2-乙二胺（VII）和1-（对氯-α-苯基苄基）-4-[2-乙氧基（2-乙氧基）-乙基]哌嗪（VIII），其中VIII是使用合成化合物鉴定的。I、V、VI、VII和VIII以前尚未见报道，但它们作为羟嗪代谢物的可能性仍不确定。
