羟嗪的气相色谱鉴定与定量：在一例致命性自服中毒中的应用

Gas chromatographic identification and quantification of hydroxyzine: application in a fatal self-poisoning.

作者信息

Kintz P, Godelar B, Mangin P

机构信息

Institut de Médecine Légale, Strasbourg, France.

出版信息

Forensic Sci Int. 1990 Dec;48(2):139-43. doi: 10.1016/0379-0738(90)90106-9.

DOI:10.1016/0379-0738(90)90106-9

PMID:2283137

Abstract

A method for the identification and quantification of hydroxyzine in human fluids by GC/NPD is presented. The method employs acepromazine as the internal standard and requires no derivatization. After a single alkaline extraction in n-heptane isoamylalcohol (98.5:1.5, v/v), analysis is achieved in 7 min. The lower limit of detectability was 0.8 ng/ml in plasma. Capillary gas chromatography mass spectrometry assay was developed for confirmation. Toxicological findings, after a fatality involving hydroxyzine are presented as an application of the procedure.

摘要

介绍了一种通过气相色谱/氮磷检测器（GC/NPD）鉴定和定量人体液中羟嗪的方法。该方法采用乙酰丙嗪作为内标，无需衍生化。在正庚烷-异戊醇（98.5:1.5，v/v）中进行单次碱性萃取后，7分钟内即可完成分析。血浆中的检测下限为0.8 ng/ml。开发了毛细管气相色谱-质谱分析法用于确证。作为该方法的应用，给出了一例涉及羟嗪致死的毒理学结果。