Hutson D G, Levi J U, Livingstone A, Zeppa R
Am Surg. 1979 Jul;45(7):449-52.
Total ligation of the pancreatic ducts of a normal gland in dogs and man results in atrophy of the acinar cells with preservation of islet cell function. Theoretically, this might be applied in the therapy of chronic pancreatitis since, in effect, an exocrine pancreatectomy results. Sustained islet cell function, as evidenced by a normal glucose tolerance test, following pancreatic duct ligation, was demonstrated in dogs for periods of up to two years. Resection of the head of the pancreas and ligation of the distal gland in six patients with chronic pancreatitis and an abnormal glucose tolerance test resulted in the development of insulin-dependent diabetes in all instances. Insulin-dependent diabetes was also demonstrated in one patient with a normal preoperative glucose tolerance test. Recurrent pancreatitis developed in only one patient. The study suggests that pancreatic duct ligation is effective in treating chronic pancreatitis but casts considerable doubt on the effectiveness of this procedure in preventing the development of diabetes, if the glucose tolerance test is abnormal
对犬类和人类正常胰腺的胰管进行完全结扎，会导致腺泡细胞萎缩，而胰岛细胞功能得以保留。从理论上讲，这或许可应用于慢性胰腺炎的治疗，因为实际上这相当于进行了一次外分泌胰腺切除术。在犬类中，通过正常的葡萄糖耐量试验证明，胰管结扎后胰岛细胞功能可持续长达两年。对6例慢性胰腺炎且葡萄糖耐量试验异常的患者进行胰头切除及胰腺远端结扎后，所有患者均发展为胰岛素依赖型糖尿病。一名术前葡萄糖耐量试验正常的患者也出现了胰岛素依赖型糖尿病。仅1例患者出现复发性胰腺炎。该研究表明，胰管结扎在治疗慢性胰腺炎方面是有效的，但如果葡萄糖耐量试验异常，对于该手术预防糖尿病发生的有效性则存在相当大的疑问。
