Pertschuk L P, Gaetjens E, Carter A C, Brigati D J, Kim D S, Tobin E H
Ann Clin Lab Sci. 1979 May-Jun;9(3):219-24.
Immunofluorescence and a new histochemical technique were employed to assay 226 breast cancer specimens for estrogen receptor. Results showed an overall correlation of 91 percent when compared to those of biochemical assays. The histochemical technique is rapid, easy to perform and reveals the same parameters as does immunofluorescence without the need for antiserum. Tumor cell receptor heterogeneity and location of receptor in cytoplasm or nucleus is readily defined by both methods. These histologic tests should prove to be useful in extending the availability of estrogen receptor analysis to all patients with breast cancer.
采用免疫荧光法和一种新的组织化学技术对226份乳腺癌标本进行雌激素受体检测。与生化检测结果相比，总体相关性为91%。该组织化学技术操作快速、简便，无需抗血清即可显示与免疫荧光相同的参数。两种方法都能很容易地确定肿瘤细胞受体的异质性以及受体在细胞质或细胞核中的位置。这些组织学检测方法应能证明在将雌激素受体分析推广应用于所有乳腺癌患者方面是有用的。
