Barton N, Bengtsson B O
Heredity (Edinb). 1986 Dec;57 ( Pt 3):357-76. doi: 10.1038/hdy.1986.135.
Suppose that selection acts at one or more loci to maintain genetic differences between hybridising populations. Then, the flow of alleles at a neutral marker locus which is linked to these selected loci will be impeded. We define and calculate measures of the barrier to gene flow between two distinct demes, and across a continuous habitat. In both cases, we find that in order for gene flow to be significantly reduced over much of the genome, hybrids must be substantially less fit, and the number of genes involved in building the barrier must be so large that the majority of other genes become closely linked to some locus which is under selection. This conclusion is not greatly affected by the pattern of epistasis, or the position of the marker locus along the chromosome.
假设选择作用于一个或多个基因座以维持杂交种群之间的遗传差异。那么，与这些被选择基因座连锁的中性标记基因座上等位基因的流动将会受到阻碍。我们定义并计算了两个不同种群之间以及跨越连续栖息地的基因流障碍的度量。在这两种情况下，我们发现，为了使全基因组的大部分区域基因流显著减少，杂种的适应性必须大幅降低，并且构建障碍所涉及的基因数量必须足够多，以至于大多数其他基因与某个处于选择作用下的基因座紧密连锁。这一结论受上位性模式或标记基因座在染色体上位置的影响不大。
