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酰基甘油结构的加热和储存与琥珀酰连接的豆甾醇残基不会引起负面的化学或生物学变化。

Heating and storage of structured acylglycerols with succinyl-linked stigmasterol residue does not cause negative chemical or biological changes.

机构信息

Faculty of Food Science and Nutrition, Poznań University of Life Sciences, Wojska Polskiego 28, 60-637, Poznań, Poland.

Department of Food Chemistry and Biocatalysis, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375, Wrocław, Poland.

出版信息

Sci Rep. 2023 Dec 4;13(1):21375. doi: 10.1038/s41598-023-48444-3.

DOI:10.1038/s41598-023-48444-3
PMID:38049600
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10695919/
Abstract

Four structured acylglycerols with stigmasterol bonded by a succinyl linker were investigated and their stability were analyzed. Samples were heated to 60 °C and kept at that temperature to simulate storage, and to 180 °C to simulate frying conditions. The degradation of the synthesized compounds and formed derivatives was determined, and their cytotoxicity and genotoxicity on normal human cells from the digestive system was determined. Holding at 180 °C resulted in greater degradation of the compounds than holding at 60 °C. The most stable compound in each sample proved to be one with oleic acid in its structure-1,3-dioleoyl-2-stigmasterylsuccinoyl-sn-glycerol (DO2SSt) at 60 °C and 1,2-dioleoyl-3-stigmasterylsuccinoyl-sn-glycerol (DO3SSt) at 180 °C. These results indicate that the type of fatty acid in the molecule is more important than its position in the glycerol structure. None of the diacylmonostigmasterylsuccinoyl-sn-glycerols (DASStGs) before or after heating exhibited cytotoxic or genotoxic potential to small intestine and colon mucosa cells.

摘要

四种通过琥珀酰基连接键与豆甾醇结合的结构酰基甘油进行了研究，并分析了它们的稳定性。将样品加热至 60°C 并保持在该温度下以模拟储存条件，加热至 180°C 以模拟油炸条件。测定了合成化合物的降解以及形成的衍生物，并测定了它们对消化系统正常人类细胞的细胞毒性和遗传毒性。在 180°C 下保持会导致化合物的降解大于在 60°C 下保持。在每种样品中最稳定的化合物被证明是其结构中具有油酸的化合物-1,3-二油酰基-2-豆甾醇琥珀酰基-sn-甘油（DO2SSt），在 60°C 下和 1,2-二油酰基-3-豆甾醇琥珀酰基-sn-甘油（DO3SSt）在 180°C 下。这些结果表明，分子中脂肪酸的类型比其在甘油结构中的位置更为重要。加热前后的二酰基单豆甾醇琥珀酰基-sn-甘油（DASStGs）均未显示出对小肠和结肠粘膜细胞的细胞毒性或遗传毒性潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8205/10695919/fbf32ed76cdb/41598_2023_48444_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8205/10695919/663339ce300b/41598_2023_48444_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8205/10695919/decfff1e9eb0/41598_2023_48444_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8205/10695919/67a85caa468a/41598_2023_48444_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8205/10695919/067231d5f315/41598_2023_48444_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8205/10695919/fbf32ed76cdb/41598_2023_48444_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8205/10695919/663339ce300b/41598_2023_48444_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8205/10695919/decfff1e9eb0/41598_2023_48444_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8205/10695919/67a85caa468a/41598_2023_48444_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8205/10695919/067231d5f315/41598_2023_48444_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8205/10695919/fbf32ed76cdb/41598_2023_48444_Fig5_HTML.jpg

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