Leon-Jimenez Pelayo, Lorenzo-Martin Maria, Tomatis-Souverbielle Cristiana, Akoghlanian Shoghik, Cripe Linda, Ramilo Octavio, Mejias Asuncion
From the Division of Infectious Diseases, Nationwide Children's Hospital.
Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children's Hospital, The Ohio State University College of Medicine.
Pediatr Infect Dis J. 2024 Mar 1;43(3):e100-e103. doi: 10.1097/INF.0000000000004203. Epub 2023 Dec 8.
We present a rare case of pan-valvular involvement in a 5-month-old female with Kawasaki disease shock syndrome despite early treatment with intravenous immunoglobulin and corticosteroids. She experienced a favorable outcome after the addition of infliximab, which was guided based on clinical, laboratory and echocardiogram findings, rather than recrudescence of fever, the most common indicator of intravenous immunoglobulin resistance.
我们报告了一例罕见的5个月大患川崎病休克综合征的女性全瓣膜受累病例,尽管早期接受了静脉注射免疫球蛋白和皮质类固醇治疗。在加用英夫利昔单抗后,她获得了良好的预后,加用英夫利昔单抗是基于临床、实验室和超声心动图检查结果来指导的,而不是根据静脉注射免疫球蛋白抵抗最常见的指标——发热复发来决定的。