Wilde David C, Glaun Mica E, Wong Michael K, Gross Neil D
Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, 1977 Butler Blvd. Suite E5.200, Houston, TX 77030, USA.
Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
Cancers (Basel). 2023 Nov 21;15(23):5494. doi: 10.3390/cancers15235494.
Surgery and external-beam radiation therapy are the primary treatment modalities for locally advanced NMSC, but they can lead to impairment of function and disfigurement in sensitive areas such as the head and neck. With the advent of targeted systemic therapies and immunotherapy, physicians have explored the ability to offer neoadjuvant therapy for NMSC in order to reduce surgically induced morbidity. Provided herein is a guide to current applications of neoadjuvant systemic therapies for NMSC and future directions.
手术和外照射放疗是局部晚期非黑色素瘤皮肤癌（NMSC）的主要治疗方式，但它们可能导致头颈部等敏感部位的功能受损和容貌毁损。随着靶向全身治疗和免疫治疗的出现，医生们探索了为NMSC提供新辅助治疗的能力，以降低手术引起的发病率。本文提供了一份关于NMSC新辅助全身治疗的当前应用及未来方向的指南。
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