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非黑色素瘤皮肤癌的天然化合物：预防与治疗。

Natural Compounds in Non-Melanoma Skin Cancer: Prevention and Treatment.

机构信息

Faculty of Medicine, Wroclaw Medical University, Pasteura 1, 50-367 Wroclaw, Poland.

Department of Psychiatry, Wroclaw Medical University, Pasteura 10, 50-367 Wroclaw, Poland.

出版信息

Molecules. 2024 Feb 4;29(3):728. doi: 10.3390/molecules29030728.

DOI:10.3390/molecules29030728
PMID:38338469
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10856721/
Abstract

The elevated occurrence of non-melanoma skin cancer (NMSC) and the adverse effects associated with available treatments adversely impact the quality of life in multiple dimensions. In connection with this, there is a necessity for alternative approaches characterized by increased tolerance and lower side effects. Natural compounds could be employed due to their safety profile and effectiveness for inflammatory and neoplastic skin diseases. These anti-cancer drugs are often derived from natural sources such as marine, zoonotic, and botanical origins. Natural compounds should exhibit anti-carcinogenic actions through various pathways, influencing apoptosis potentiation, cell proliferation inhibition, and metastasis suppression. This review provides an overview of natural compounds used in cancer chemotherapies, chemoprevention, and promotion of skin regeneration, including polyphenolic compounds, flavonoids, vitamins, alkaloids, terpenoids, isothiocyanates, cannabinoids, carotenoids, and ceramides.

摘要

非黑色素瘤皮肤癌（NMSC）的发生率升高，以及现有治疗方法相关的不良反应，从多个方面对生活质量产生了不利影响。有鉴于此，我们需要寻找具有更高耐受性和更低副作用的替代方法。天然化合物由于其安全性和对炎症性及肿瘤性皮肤病的有效性，可被应用于相关治疗。这些抗癌药物通常源自天然来源，如海洋、动物源和植物源。天然化合物可以通过多种途径发挥抗癌作用，包括促进细胞凋亡、抑制细胞增殖和抑制转移等。本综述概述了用于癌症化疗、化学预防和促进皮肤再生的天然化合物，包括多酚类化合物、类黄酮、维生素、生物碱、萜类化合物、异硫氰酸盐、大麻素、类胡萝卜素和神经酰胺。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acdc/10856721/ef3216686af5/molecules-29-00728-g011.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acdc/10856721/223c89fcde63/molecules-29-00728-g008.jpg
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