Stefanou Amalia J, Dessureault Sophie, Sanchez Julian, Felder Seth
Clinical and Pathologic Response to Therapy in Gastrointestinal Oncology, Moffitt Cancer Center, 12902 Magnolia Dr., Tampa, FL 33612, USA.
Cancers (Basel). 2023 Nov 22;15(23):5535. doi: 10.3390/cancers15235535.
Local tumor response evaluation following neoadjuvant treatment(s) in rectal adenocarcinoma requires a multi-modality approach including physical and endoscopic evaluations, rectal protocoled MRI, and cross-sectional imaging. Clinical tumor response exists on a spectrum from complete clinical response (cCR), defined as the absence of clinical evidence of residual tumor, to near-complete response (nCR), which assumes a significant reduction in tumor burden but with increased uncertainty of residual microscopic disease, to incomplete clinical response (iCR), which incorporates all responses less than nCR that is not progressive disease. This article aims to review the clinical tools currently routinely available to evaluate treatment response and offers a potential management approach based on the extent of local tumor response.
直肠癌新辅助治疗后的局部肿瘤反应评估需要采用多模态方法，包括体格检查和内镜评估、直肠规范化MRI以及横断面成像。临床肿瘤反应范围包括完全临床缓解（cCR），即无残留肿瘤的临床证据；接近完全缓解（nCR），即肿瘤负荷显著降低，但残留微小病灶的不确定性增加；不完全临床缓解（iCR），包括所有小于nCR且非疾病进展的反应。本文旨在综述目前常规用于评估治疗反应的临床工具，并根据局部肿瘤反应程度提供一种潜在的管理方法。
