Krinski Gabriela, Bertin Larissa Dragonetti, Pimpão Heloise Angélico, Silva Humberto, Tavares Brunna Luiza, Lunardelli Leonardo, Alves do Prado Geovana, Pitta Fabio, Camillo Carlos Augusto
Laboratory of Research in Respiratory Physiotherapy, Department of Physiotherapy, State University of Londrina, Londrina 86038-350, Brazil.
Department of Rehabilitation Sciences, Pitágoras Unopar Anhanguera University, Campus Piza, Londrina 86041-140, Brazil.
J Clin Med. 2023 Nov 25;12(23):7314. doi: 10.3390/jcm12237314.
End-of-life care (EOLC) is palliative support provided in the last 6 months to 1 year of a patient's life. Although there are established criteria for its indication, few studies describe the clinical and functional characteristics of individuals with interstitial lung diseases (ILD) in EOLC. ILD individuals underwent various assessments, including lung function, exercise capacity (6 min walk test), physical activity in daily life (PADL), peripheral muscle strength, maximal respiratory pressures, body composition, quality of life (SGRQ-I), symptoms of anxiety and depression, dyspnea (MRC scale), and sleep quality. Fifty-eight individuals were included and divided into two groups according to the indication for commencing EOLC (ILD with an indication of EOLC (ILD-EOLC) or ILD without an indication of EOLC (ILD-nEOLC). There were differences between the groups, respectively, for steps/day (2328 [1134-3130] vs. 5188 [3863-6514] n/day, = 0.001), time spent/day carrying out moderate-to-vigorous physical activities (1 [0.4-1] vs. 10 [3-19] min/day, = 0.0003), time spent/day in standing (3.8 [3.2-4.5] vs. 4.8 [4.1-6.7] h/day, = 0.005), and lying positions (5.7 [5.3-6.9] vs. 4.2 [3.6-5.1] h/day, = 0.0004), the sit-to-stand test (20 ± 4 vs. 26 ± 7 reps, = 0.01), 4 m gait speed (0.92 ± 0.21 vs. 1.05 ± 0.15 m/s, = 0.02), quadriceps muscle strength (237 [211-303] vs. 319 [261-446] N, = 0.005), SGRQ-I (71 ± 15 vs. 50 ± 20 pts, = 0.0009), and MRC (4 [3-5] vs. 2 [2-3] pts, = 0.001). ILD individuals with criteria for commencing EOLC exhibit reduced PADL, functional performance, peripheral muscle strength, quality of life, and increased dyspnea.
临终关怀（EOLC）是在患者生命的最后6个月至1年提供的姑息性支持。尽管其适应证有既定标准，但很少有研究描述临终关怀中患有间质性肺疾病（ILD）个体的临床和功能特征。ILD个体接受了各种评估，包括肺功能、运动能力（6分钟步行试验）、日常生活中的身体活动（PADL）、外周肌肉力量、最大呼吸压力、身体成分、生活质量（SGRQ-I）、焦虑和抑郁症状、呼吸困难（MRC量表）以及睡眠质量。纳入了58名个体，并根据开始临终关怀的适应证分为两组（有临终关怀适应证的ILD（ILD-EOLC）或无临终关怀适应证的ILD（ILD-nEOLC））。两组在以下方面分别存在差异：每天步数（2328 [1134 - 3130]对5188 [3863 - 6514]步/天，P = 0.001）、每天进行中度至剧烈身体活动的时间（1 [0.4 - 1]对10 [3 - 19]分钟/天，P = 0.0003）、每天站立时间（3.8 [3.2 - 4.5]对4.8 [4.1 - 6.7]小时/天，P = 0.005）以及躺卧时间（5.7 [5.3 - 6.9]对4.2 [3.6 - 5.1]小时/天，P = 0.0004）、从坐到站测试（20 ± 4对26 ± 7次重复，P = 0.01）、4米步态速度（0.92 ± 0.21对1.05 ± 0.15米/秒，P = 0.02）、股四头肌力量（237 [211 - 303]对319 [261 - 446]牛顿，P = 0.005）、SGRQ-I（71 ± 15对50 ± 20分，P = 0.0009）以及MRC（4 [3 - 5]对2 [2 - 3]分，P = 0.001）。有临终关怀适应证标准的ILD个体表现出PADL降低、功能表现下降、外周肌肉力量减弱、生活质量下降以及呼吸困难加重。
