Department of Diseases of the Thorax, GB Morgagni Hospital, Asl Romagna, Forlì, Italy.
Sleep Disorders Center, Department of Medicine and Surgery, University of Parma, Italy.
Respir Med. 2019 Feb;147:51-57. doi: 10.1016/j.rmed.2018.12.018. Epub 2019 Jan 10.
the study aims at describing the role of sleep disordered breathing (SDB) on daytime symptoms, quality of sleep and quality of life (QoL) in patients with moderate-severe IPF.
we enrolled 34 consecutive room air breathing IPF outpatients who received a full-night polysomnography. The following questionnaires were administered: Epworth Sleepiness Score (ESS), Pittsburg Sleep Quality Index (PSQI), StGeorge's Questionnaire (StGQ).
patients were classified in 3 groups:Group A (NO-SDB, 9 patients), Group B(OSAS without sleep-related hypoxemia, 17 patients), Group C(OSAS with sleep-related hypoxemia, 8 patients). Although sleep parameters showed no significant differences among the 3 groups, worse measures were found in group C. 50% of patients (17/34) reported a StGQ score indicating a reduced QoL and the StGQ score was significantly higher in group C patients compared to group A (p < 0.05). In the stepwise multiple regression analysis, 75% of StGQ score variability was significantly predicted by FVC(Forced Vital Capacity) %, DLco (diffusion lung capacity for carbon monoxide)%, PSQI and ESS.
in patients with IPF both subjective and polysomnographic poor sleep quality are extremely common features, they are predicted by variables associated with SBD severity and are linked to low QoL. IPF with more severe SDB present poor sleep quality and a worse QoL compared to SDB-free or OSAS-only.
本研究旨在描述睡眠呼吸障碍（SDB）对中重度特发性肺纤维化（IPF）患者日间症状、睡眠质量和生活质量（QoL）的影响。
我们纳入了 34 名连续的在室气呼吸的 IPF 门诊患者，他们接受了整晚多导睡眠图检查。同时还进行了以下问卷调查：Epworth 嗜睡量表（ESS）、匹兹堡睡眠质量指数（PSQI）、圣乔治呼吸问卷（StGQ）。
患者被分为 3 组：A 组（无 SDB，9 例）、B 组（无睡眠相关低氧血症的 OSAS，17 例）、C 组（有睡眠相关低氧血症的 OSAS，8 例）。尽管 3 组之间的睡眠参数没有显著差异，但 C 组的测量结果更差。50%的患者（34 例中有 17 例）报告 StGQ 评分表明 QoL 降低，且 C 组患者的 StGQ 评分明显高于 A 组（p<0.05）。在逐步多元回归分析中，StGQ 评分的 75%可由 FVC（用力肺活量）%、DLco（一氧化碳弥散量）%、PSQI 和 ESS 显著预测。
在 IPF 患者中，主观和多导睡眠图记录的睡眠质量差是非常常见的特征，它们由与 SBD 严重程度相关的变量预测，并与低 QoL 相关。与无 SDB 或仅有 OSAS 相比，SDB 更严重的 IPF 患者睡眠质量差，QoL 更差。
