University of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Brasília, DF 70910-900, Brazil.
University of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Brasília, DF 70910-900, Brazil.
Growth Horm IGF Res. 2023 Oct-Dec;72-73:101561. doi: 10.1016/j.ghir.2023.101561. Epub 2023 Dec 5.
The role of the insulin-like growth factor (IGF) system has attracted close attention. The activity of IGF binding proteins (IGFBPs) within the ovary has not been fully elucidated to date. These proteins bind to IGF with an equal, or greater, affinity than to the IGF1 receptor, thus being in the main position to regulate IGF signalling, in addition to extending the half-life of IGFs within the bloodstream and promoting IGF storage in specific tissue niches. IGF1 has an important part in cell proliferation, differentiation and apoptosis. Considering the importance of IGFs in oocyte maturation, this review sought to elucidate aspects including: IGF production mechanisms; constituent members of their family and their respective functions; the role that these factors play during folliculogenesis, together with their functions during oocyte maturation and apoptosis, and their performance during luteal development. This review also explores the role of IGFs in biotechnological applications, focusing specifically on animal genetic gain.
胰岛素样生长因子（IGF）系统的作用引起了密切关注。迄今为止，卵巢内 IGF 结合蛋白（IGFBPs）的活性尚未得到充分阐明。这些蛋白与 IGF 的结合亲和力与 IGF1 受体相等或更高，因此除了延长 IGF 在血液中的半衰期并促进 IGF 在特定组织龛中的储存外，它们主要能够调节 IGF 信号转导。IGF1 在细胞增殖、分化和凋亡中起着重要作用。鉴于 IGF 在卵母细胞成熟中的重要性，本综述旨在阐明以下方面：IGF 的产生机制；它们的家族组成成员及其各自的功能；这些因素在卵泡发生过程中的作用，以及它们在卵母细胞成熟和凋亡中的功能，以及它们在黄体发育过程中的表现。本综述还探讨了 IGF 在生物技术应用中的作用，特别是在动物遗传增益方面。
