Harden Joel E, Tabacu Lucia, Reynolds Leryn J
School of Exercise Science, Old Dominion University, Norfolk, VA, USA.
Department of Mathematics and Statistics, Old Dominion University, Norfolk, VA, USA.
Diabetes Res Clin Pract. 2024 Jan;207:111047. doi: 10.1016/j.diabres.2023.111047. Epub 2023 Dec 7.
To investigate associations between objectively measured light (LPA) and moderate-to-vigorous (MVPA) physical activity on plasma homocysteine and serum C-reactive protein (CRP) in individuals with Non-Alcoholic Fatty Liver Disease (NAFLD).
This study was a secondary analysis using data from 2003 to 2006 National Health and Nutrition Examination Survey including a total of 983 individuals with NAFLD. Physical activity was assessed over 7 days with accelerometers. Participants were split into tertiles based on average daily minutes of LPA or MVPA and CRP and homocysteine were assessed across tertiles.
Adjusted plasma homocysteine and CRP were not different between groups regarding levels of LPA (Homocysteine: 1st tertile - 10.4 ± 0.7 µmol/L; 2nd tertile - 9.6 ± 0.4 µmol/L; 3rd tertile - 9.6 ± 0.4 µmol/L; p = 0.28; CRP: 1st tertile - 0.79 ± 0.12 mg/dL; 2nd tertile - 0.73 ± 0.09 mg/dL; 3rd tertile - 0.73 ± 0.09 mg/dL; p = 0.72). Adjusted CRP was significantly (p = 0.02) different across MVPA tertiles (1st: 0.87 ± 0.13 mg/dL; 2nd: 0.75 ± 0.10 mg/dL; 3rd:0.65 ± 0.09).
LPA does not appear to be effective at improving homocysteine or CRP levels in individuals with NAFLD. However, MVPA may be an effective therapy for decreasing CRP in NAFLD patients.
研究客观测量的轻度身体活动（LPA）和中度至剧烈身体活动（MVPA）与非酒精性脂肪性肝病（NAFLD）患者血浆同型半胱氨酸和血清C反应蛋白（CRP）之间的关联。
本研究是一项二次分析，使用了2003年至2006年全国健康与营养检查调查的数据，共纳入983例NAFLD患者。使用加速度计评估7天的身体活动情况。参与者根据平均每日LPA或MVPA分钟数分为三分位数，并对三分位数的CRP和同型半胱氨酸进行评估。
就LPA水平而言，各组之间调整后的血浆同型半胱氨酸和CRP无差异（同型半胱氨酸：第一三分位数-10.4±0.7µmol/L；第二三分位数-9.6±0.4µmol/L；第三三分位数-9.6±0.4µmol/L；p=0.28；CRP：第一三分位数-0.79±0.12mg/dL；第二三分位数-0.73±0.09mg/dL；第三三分位数-0.73±0.09mg/dL；p=0.72）。MVPA三分位数之间调整后的CRP有显著差异（p=0.02）（第一：0.87±0.13mg/dL；第二：0.75±0.10mg/dL；第三：0.65±0.09）。
LPA似乎对改善NAFLD患者的同型半胱氨酸或CRP水平无效。然而，MVPA可能是降低NAFLD患者CRP的有效疗法。
