严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染在促发异常免疫反应和脓毒症中的作用：SARS-CoV-2相关脓毒症与其他原因所致脓毒症的比较
The role of SARS-COV-2 infection in promoting abnormal immune response and sepsis: A comparison between SARS-COV-2-related sepsis and sepsis from other causes.
作者信息
Piccioni Andrea, Franza Laura, Rosa Federico, Candelli Marcello, Covino Marcello, Ferrara Michela, Volonnino Gianpietro, Bertozzi Giuseppe, Vittoria Zamponi Maria, Maiese Aniello, Savioli Gabriele, Franceschi Francesco, La Russa Raffaele
机构信息
Department of Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, 1-00168 Rome, Italy.
Università Cattolica del Sacro Cuore, 1-00168 Rome, Italy.
出版信息
Infect Med (Beijing). 2023 Apr 28;2(3):202-211. doi: 10.1016/j.imj.2023.04.006. eCollection 2023 Sep.
BACKGROUND
COVID-19 caused by SARS-CoV-2 virus is characterized by respiratory compromise and immune system involvement, even leading to serious disorders, such as cytokine storm.
METHODS
We then conducted a literature review on the topic of sepsis and covid-19, and in parallel conducted an experimental study on the histological finding of patients who died from SARS-Covid 19 infection and a control group.
RESULTS
Sepsis associated with covid-19 infection has some similarities and differences from that from other causes.
CONCLUSION
In this paper the complex interplay between the 2 disorders was discussed, focusing on the similarities and on the effect that one could have on the other. A preliminary experimental section that demonstrates the multisystemic involvement in subjects who die from SARS-CoV-2 is also proposed.
背景
由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）病毒引起的2019冠状病毒病（COVID-19）的特征是呼吸功能受损和免疫系统受累，甚至会导致严重病症，如细胞因子风暴。
方法
我们随后对脓毒症和COVID-19这一主题进行了文献综述，并同时对死于SARS-CoV-2感染的患者及一个对照组进行了组织学检查的实验研究。
结果
与COVID-19感染相关的脓毒症与其他原因引起的脓毒症有一些异同之处。
结论
本文讨论了这两种病症之间的复杂相互作用，重点关注它们的相似之处以及彼此可能产生的影响。还提出了一个初步的实验部分，以证明死于SARS-CoV-2的患者存在多系统受累情况。
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