Wang Hang, Zhang Liyi, Wu Jie, Wang Pengpeng, Li Qiang, Sui Xinyao, Xu Yaqi, Zhao Yue, Liu Yang, Zhang Yunhui
Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China (Fudan University), Shanghai 200032, China.
Key Laboratory of Public Health Safety, Ministry of Education, School of Public Health, Fudan University, Shanghai 200032, China.
Eco Environ Health. 2023 Jul 15;2(3):152-160. doi: 10.1016/j.eehl.2023.07.003. eCollection 2023 Sep.
The connections between urinary organophosphate ester (OPE) metabolites and child growth have been identified in prior research, but there is currently a dearth of epidemiological evidence regarding the sex-specific impact of OPEs on child growth trajectories. This study enrolled 804 maternal-child pairs, and five OPE congeners were quantified in maternal serum during pregnancy. In this study, the impact of prenatal OPE exposure on child growth trajectories was assessed using linear mixed-effect models and a group-based trajectory model (GBTM), with consideration given to sex-specific effects. Fetuses were frequently exposed to OPEs in utero, and tris(2-butoxyethel) phosphate (TBEP) exhibited the highest concentration levels in maternal serum. Among male children, an increase of 2.72 ng/g lipid in TBEP concentration was associated with a 0.11-unit increase in head circumference-for-age z-score (HCAZ), and the effect was mainly concentrated at 1 and 2 months of age. Among female children, an increase of 2.72 ng/g lipid in tris(2-chloro-1-(chloromethyl) ethyl) phosphate (TDCPP) concentration was associated with a 0.15-unit increase in length-for-age z-score (LAZ) and a 0.14-unit increase in weight-for-age z-score (WAZ), and the effects were mainly concentrated at 9 months of age. For HCAZ trajectories, higher prenatal TBEP exposure was associated with higher odds for the fast growth group in male children. For the LAZ and WAZ trajectories, higher prenatal TDCPP exposure was associated with higher odds for the fast growth group in female children. The trajectory analysis approach provided insight into the complex associations between OPE exposure and child growth.
先前的研究已经确定了尿中有机磷酸酯（OPE）代谢物与儿童生长之间的联系，但目前缺乏关于OPE对儿童生长轨迹性别特异性影响的流行病学证据。本研究纳入了804对母婴，在孕期对母体血清中的五种OPE同系物进行了定量分析。在本研究中，使用线性混合效应模型和基于群体的轨迹模型（GBTM）评估产前OPE暴露对儿童生长轨迹的影响，并考虑了性别特异性效应。胎儿在子宫内经常暴露于OPE，其中磷酸三（2-丁氧基乙基）酯（TBEP）在母体血清中的浓度水平最高。在男童中，TBEP浓度每增加2.72 ng/g脂质，年龄别头围z评分（HCAZ）增加0.11个单位，且该效应主要集中在1个月和2个月龄时。在女童中，磷酸三（2-氯-1-（氯甲基）乙基）酯（TDCPP）浓度每增加2.72 ng/g脂质，年龄别身长z评分（LAZ）增加0.15个单位，年龄别体重z评分（WAZ）增加0.14个单位，且该效应主要集中在9个月龄时。对于HCAZ轨迹，产前TBEP暴露较高与男童快速生长组的较高几率相关。对于LAZ和WAZ轨迹，产前TDCPP暴露较高与女童快速生长组的较高几率相关。轨迹分析方法为深入了解OPE暴露与儿童生长之间的复杂关联提供了思路。
