Medical Imaging Center, Departments of Radiology, Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, The Netherlands.
Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, The Netherlands.
Clin Exp Rheumatol. 2023 Dec;41(12):2428-2436. doi: 10.55563/clinexprheumatol/8qt9me. Epub 2023 Dec 5.
Wide variety in salivary gland 18F-FDG-uptake is observed in the general population. A general consensus about the usefulness of 18F-FDG-PET/CT to detect salivary gland inflammatory conditions, such as in primary Sjögren's syndrome (pSS), is not yet clear. This study aimed to investigate whether there are differences in uptake of 18F-FDG in salivary glands among two autoimmune groups [pSS, giant cell arteritis (GCA)] and a non-autoimmune group (lung cancer).
PSS patients aged ≥50 years who underwent 18F-FDG-PET/CT were included and age-matched with GCA patients and a non-autoimmune control group (lung cancer patients). Scans were visually evaluated and quantitative analysis was performed by measuring standardised uptake values (SUV) within salivary glands and lacrimal glands. For GCA patients, arteries in the vicinity of the parotid and submandibular gland were assessed for positivity.
PSS patients did not show increased 18F-FDG-uptake in the parotid or submandibular gland, compared to the other two groups. For the tubarial gland, significantly higher SUVmax was found in the pSS patient group. Interestingly, GCA patients had significantly higher SUVmax in the submandibular gland than the other two groups. Visual 18F-FDG-positivity of cranial arteries related to the parotid and submandibular glands was associated with significantly higher SUVmax in salivary glands of GCA patients.
Although 18F-FDG-uptake was not increased in parotid and submandibular glands of pSS patients, increased 18F-FDG-uptake in tubarial glands of pSS patients might indicate a role for these glands in pSS. Furthermore, parotid and submandibular glands may be affected by local vasculitis in GCA.
在普通人群中，观察到唾液腺 18F-FDG 摄取的种类繁多。目前对于 18F-FDG-PET/CT 检测唾液腺炎症性疾病（如原发性干燥综合征（pSS））的有用性尚未达成共识。本研究旨在探讨在两个自身免疫性疾病组（pSS、巨细胞动脉炎（GCA））和一个非自身免疫性疾病组（肺癌）中，唾液腺摄取 18F-FDG 是否存在差异。
纳入年龄≥50 岁且接受 18F-FDG-PET/CT 的 pSS 患者，并与 GCA 患者和非自身免疫性对照组（肺癌患者）进行年龄匹配。通过视觉评估和测量唾液腺和泪腺内的标准化摄取值（SUV）进行定量分析。对于 GCA 患者，评估了腮腺和下颌下腺附近动脉的阳性情况。
与其他两组相比，pSS 患者的腮腺和下颌下腺 18F-FDG 摄取并未增加。对于管周腺，pSS 患者组的 SUVmax 显著更高。有趣的是，GCA 患者的下颌下腺 SUVmax 显著高于其他两组。与腮腺和下颌下腺相关的颅动脉的 18F-FDG 阳性与 GCA 患者唾液腺 SUVmax 显著升高相关。
尽管 pSS 患者的腮腺和下颌下腺 18F-FDG 摄取未增加，但 pSS 患者的管周腺 18F-FDG 摄取增加可能表明这些腺体在 pSS 中发挥作用。此外，GCA 中可能存在局部血管炎累及腮腺和下颌下腺。
