Quantitative Diagnostic Imaging, Field of Oral and Maxillofacial Imaging and Histopathological Diagnostics, Course of Applied Science, The Nippon Dental University Graduate School of Life Dentistry at Niigata, Niigata, Japan.
Department of Oral and Maxillofacial Radiology, The Nippon Dental University School of Life Dentistry at Niigata, Niigata, Japan.
Gerodontology. 2022 Sep;39(3):297-301. doi: 10.1111/ger.12584. Epub 2021 Jul 20.
This study examined whether time-activity curves (TAC) can be used to differentiate between patients with and without Sjögren's syndrome using SPECT/CT.
Thirteen xerostomia patients (5 with Sjögren's syndrome and 8 without Sjögren's syndrome) underwent SPECT/CT. Salivary gland secretion data were digitally observed, producing separate time-activity curves (TAC) for the submandibular glands and parotid glands using SPECT/CT. The salivary gland secretion fraction was defined as A (before stimulation test [counts/frame]) divided by B (after stimulation test [counts/frame]). The A/B ratios of patients with Sjögren's syndrome and those without Sjögren's syndrome were compared using the Mann-Whitney U test for nonparametric data.
The A/B ratio of parotid glands with Sjögren's syndrome (1.3 ± 0.2) was significantly lower than for those without Sjögren's syndrome (2.7 ± 0.7). The A/B ratio of submandibular glands with Sjögren's syndrome (1.3 ± 0.4) is significantly lower than for those without Sjögren's syndrome (1.8 ± 0.6).
The TAC for the submandibular glands and parotid glands using SPECT/CT may be useful for the objective and quantitative diagnosis of Sjögren's syndrome.
本研究旨在探讨使用 SPECT/CT 是否可以通过时间-活性曲线（TAC）区分干燥综合征患者和非干燥综合征患者。
13 例口干症患者（5 例干燥综合征，8 例非干燥综合征）进行了 SPECT/CT 检查。使用 SPECT/CT 对唾液腺分泌数据进行数字观察，为颌下腺和腮腺分别生成单独的时间-活性曲线（TAC）。唾液腺分泌分数定义为 A（刺激试验前[计数/帧]）除以 B（刺激试验后[计数/帧]）。使用非参数数据的曼-惠特尼 U 检验比较干燥综合征患者和非干燥综合征患者的 A/B 比值。
干燥综合征患者的腮腺 A/B 比值（1.3±0.2）明显低于非干燥综合征患者（2.7±0.7）。干燥综合征患者的颌下腺 A/B 比值（1.3±0.4）明显低于非干燥综合征患者（1.8±0.6）。
使用 SPECT/CT 的颌下腺和腮腺 TAC 可能有助于干燥综合征的客观和定量诊断。
