Xu Huijing, Scholten Kee, Li Zijia, Meng Ellis, Song Dong
Annu Int Conf IEEE Eng Med Biol Soc. 2023 Jul;2023:1-4. doi: 10.1109/EMBC40787.2023.10340804.
Large-scale network recording technology is critical in linking neural activity to behavior. Stable, long-term recordings collected from behaving animals are the foundation for understanding neural dynamics and the plasticity of neural circuits. Penetrating microelectrode arrays (MEAs) can obtain high-resolution neural activity from different brain regions. However, ensuring the longevity of implantable devices and the consistency of neural signals over time remains one big challenge. A potential solution is to use flexible, polymer-based MEAs to minimize the foreign body response and prolong the lifetime of neural interfacing devices. Rodents and nonhuman primates (NHP) are commonly used animal models in neuroscience and neuroengineering studies. Specially designed MEAs that capture morphological features of different animal brains and various brain structures are powerful tools to simultaneously obtain neural activities from multiple brain regions. In this work, we develop a set of prototype designs of polymer MEAs that cover cortical, sub-cortical, and multiple brain regions of rodents and NHP.
大规模网络记录技术对于将神经活动与行为联系起来至关重要。从行为动物身上收集的稳定、长期记录是理解神经动力学和神经回路可塑性的基础。穿透式微电极阵列（MEA）可以从不同脑区获取高分辨率的神经活动。然而，确保可植入设备的寿命以及神经信号随时间的一致性仍然是一个巨大的挑战。一个潜在的解决方案是使用基于聚合物的柔性MEA，以尽量减少异物反应并延长神经接口设备的使用寿命。啮齿动物和非人类灵长类动物（NHP）是神经科学和神经工程研究中常用的动物模型。专门设计的MEA能够捕捉不同动物大脑和各种脑结构的形态特征，是同时从多个脑区获取神经活动的有力工具。在这项工作中，我们开发了一组聚合物MEA的原型设计，其覆盖了啮齿动物和NHP的皮质、皮质下及多个脑区。
