Gong Yan, Liu Xiang, Jiang Zebin, Weber Arthur, Li Wen
Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI, USA.
Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA.
Microsyst Nanoeng. 2025 May 6;11(1):76. doi: 10.1038/s41378-024-00842-x.
This paper presents a thin-film, three-dimensional (3D) opto-electro array featuring four addressable microscale light-emitting diodes (LEDs) for surface cortex illumination and nine penetrating electrodes for simultaneous recording of light-evoked neural activities. Inspired by the origami concept, we have developed a meticulously designed "bridge+trench" structure that facilitates the transformation of the array from 2D to 3D while preventing damage to the thin film metal. Prior to device transformation, the shape and dimensions of the 2D array can be customized, enhancing its versatility for various applications. In addition, the arched base offers strong mechanical support to facilitate the direct insertion of the probe into tissue without any mechanical reinforcement. The array was encapsulated using polyimide and epoxy to ensure mechanical flexibility and biocompatibility of the device. The efficacy of the device was evaluated through comprehensive in vitro and in vivo characterization.
本文介绍了一种薄膜三维（3D）光电阵列，其具有四个用于表面皮质照明的可寻址微型发光二极管（LED）和九个用于同时记录光诱发神经活动的穿透电极。受折纸概念启发，我们开发了一种精心设计的“桥+沟”结构，该结构有助于阵列从二维转换为三维，同时防止薄膜金属受损。在器件转换之前，可以定制二维阵列的形状和尺寸，增强其在各种应用中的通用性。此外，拱形基座提供了强大的机械支撑，便于在没有任何机械加固的情况下将探针直接插入组织。该阵列用聚酰亚胺和环氧树脂封装，以确保器件的机械柔韧性和生物相容性。通过全面的体外和体内表征评估了该器件的功效。
