超越抗病毒：细菌诱导的干扰素维持肠道中的耐受性。

Beyond antiviral: Interferon induced by bacteria maintains tolerance in the gut.

机构信息

Division of Gastroenterology and Hepatology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

出版信息

J Exp Med. 2024 Jan 1;221(1). doi: 10.1084/jem.20232011. Epub 2023 Dec 13.

DOI:10.1084/jem.20232011

PMID:38091026

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10720530/

Abstract

Type I interferons are best known for their antiviral role. Here, Ayala et al. (https://doi.org/10.1084/jem.20230063) reveal that commensal bacteria elicit tonic type I interferons to prime dendritic cells and induce regulatory T cells that maintain a tolerogenic intestinal milieu.

摘要

I 型干扰素以其抗病毒作用而闻名。在这里，Ayala 等人（https://doi.org/10.1084/jem.20230063）揭示了共生菌会引发持续的 I 型干扰素，以激活树突状细胞并诱导调节性 T 细胞，从而维持肠道的免疫耐受环境。