Department of Cardiology, Xi'an No.3 Hospital, The Affiliated Hospital of Northwest University. Faculty of Life Sciences and Medicine, Northwest University, 10 Fengcheng Three Road, Xi'an, China; Xi'an Key Laboratory of Innovative Drug Research for Heart Failure, Faculty of Life Sciences and Medicine, Northwest University, 229 Taibai North Road, Xi'an, China.
Department of Cardiothoracic Surgery, Central Theater Command General Hospital of Chinese People's Liberation Army, 627 Wuluo Road, Wuhan, China.
Ageing Res Rev. 2024 Jan;93:102163. doi: 10.1016/j.arr.2023.102163. Epub 2023 Dec 11.
Cardiovascular disease (CVD) is the primary global cause of death, and inflammation is a crucial factor in the development of CVDs. The acute phase inflammatory protein pentraxin 3 (PTX3) is a biomarker reflecting the immune response. Recent research indicates that PTX3 plays a vital role in CVDs and has been investigated as a possible biomarker for CVD in clinical trials. PTX3 is implicated in the progression of CVDs through mechanisms such as exacerbating vascular endothelial dysfunction, affecting angiogenesis, and regulating inflammation and oxidative stress. This review summarized the structure and function of PTX3, focusing on its multifaceted effects on CVDs, such as atherosclerosis, myocardial infarction, and hypertension. This may help in explaining the varying PTX3 functions and usage, as well as in utilizing target organs to manage diseases. Moreover, elucidating the opposite role of PTX3 in the cardiovascular system will demonstrate the therapeutic and predictive potential in human diseases.
心血管疾病（CVD）是全球主要的死亡原因，炎症是 CVD 发展的关键因素。急性时相炎症蛋白 pentraxin 3（PTX3）是反映免疫反应的生物标志物。最近的研究表明，PTX3 在 CVD 中起着至关重要的作用，并已在临床试验中被作为 CVD 的潜在生物标志物进行研究。PTX3 通过加重血管内皮功能障碍、影响血管生成以及调节炎症和氧化应激等机制参与 CVD 的进展。本综述总结了 PTX3 的结构和功能，重点介绍了其在动脉粥样硬化、心肌梗死和高血压等 CVD 中的多方面作用。这有助于解释 PTX3 功能和用途的差异，并利用靶器官来治疗疾病。此外，阐明 PTX3 在心血管系统中的相反作用将展示其在人类疾病中的治疗和预测潜力。
