Department of Medical Informatics, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands.
National Intensive Care Evaluation Foundation, Amsterdam, The Netherlands.
Crit Care Med. 2024 Apr 1;52(4):574-585. doi: 10.1097/CCM.0000000000006156. Epub 2023 Dec 14.
Strain on ICUs during the COVID-19 pandemic required stringent triage at the ICU to distribute resources appropriately. This could have resulted in reduced patient volumes, patient selection, and worse outcome of non-COVID-19 patients, especially during the pandemic peaks when the strain on ICUs was extreme. We analyzed this potential impact on the non-COVID-19 patients.
A national cohort study.
Data of 71 Dutch ICUs.
A total of 120,393 patients in the pandemic non-COVID-19 cohort (from March 1, 2020 to February 28, 2022) and 164,737 patients in the prepandemic cohort (from January 1, 2018 to December 31, 2019).
None.
Volume, patient characteristics, and mortality were compared between the pandemic non-COVID-19 cohort and the prepandemic cohort, focusing on the pandemic period and its peaks, with attention to strata of specific admission types, diagnoses, and severity. The number of admitted non-COVID-19 patients during the pandemic period and its peaks were, respectively, 26.9% and 34.2% lower compared with the prepandemic cohort. The pandemic non-COVID-19 cohort consisted of fewer medical patients (48.1% vs. 50.7%), fewer patients with comorbidities (36.5% vs. 40.6%), and more patients on mechanical ventilation (45.3% vs. 42.4%) and vasoactive medication (44.7% vs. 38.4%) compared with the prepandemic cohort. Case-mix adjusted mortality during the pandemic period and its peaks was higher compared with the prepandemic period, odds ratios were, respectively, 1.08 (95% CI, 1.05-1.11) and 1.10 (95% CI, 1.07-1.13).
In non-COVID-19 patients the strain on healthcare has driven lower patient volume, selection of fewer comorbid patients who required more intensive support, and a modest increase in the case-mix adjusted mortality.
COVID-19 大流行期间,对 ICU 的压力要求对 ICU 进行严格的分类,以合理分配资源。这可能导致非 COVID-19 患者的患者数量减少、患者选择减少以及非 COVID-19 患者的预后更差,尤其是在 ICU 压力极大的大流行高峰期。我们分析了这对非 COVID-19 患者的潜在影响。
一项全国性队列研究。
71 家荷兰 ICU 的数据。
共纳入大流行期间非 COVID-19 队列(2020 年 3 月 1 日至 2022 年 2 月 28 日)中的 120393 例患者和大流行前队列(2018 年 1 月 1 日至 2019 年 12 月 31 日)中的 164737 例患者。
无。
比较大流行期间非 COVID-19 队列和大流行前队列的患者数量、患者特征和死亡率,重点关注大流行期间及其高峰期,并注意特定入院类型、诊断和严重程度的分层。大流行期间和高峰期收治的非 COVID-19 患者数量分别比大流行前队列减少了 26.9%和 34.2%。与大流行前队列相比,大流行期间非 COVID-19 队列中接受治疗的患者中,内科患者比例较低(48.1% vs. 50.7%),合并症患者比例较低(36.5% vs. 40.6%),接受机械通气(45.3% vs. 42.4%)和血管活性药物治疗(44.7% vs. 38.4%)的患者比例较高。大流行期间和高峰期的病例组合调整死亡率与大流行前时期相比更高,比值比分别为 1.08(95%可信区间,1.05-1.11)和 1.10(95%可信区间,1.07-1.13)。
在非 COVID-19 患者中,医疗保健的压力导致患者数量减少、选择合并症较少的患者,这些患者需要更强化的支持,并且病例组合调整后的死亡率略有增加。