School of Life Sciences, Chongqing University, Chongqing 401331, China.
Institute of Basic Medicine and Forensic Medicine, North Sichuan Medical College, Nanchong 637000, Sichuan, China.
J Agric Food Chem. 2023 Dec 27;71(51):20613-20624. doi: 10.1021/acs.jafc.3c05748. Epub 2023 Dec 15.
Pathogenic oomycetes infect a wide variety of organisms, including plants, animals, and humans, and cause massive economic losses in global agriculture, aquaculture, and human health. Salicylic acid (SA), an endogenous phytohormone, is regarded as an inducer of plant immunity. Here, the potato late blight pathogen was used as a model system to uncover the inhibitory mechanisms of SA on pathogenic oomycetes. In this research, SA significantly inhibited the mycelial growth, sporulation, sporangium germination, and virulence of . Inhibition was closely related to enhanced autophagy, suppression of translation initiation, and ribosomal biogenesis in , as shown by multiomics analysis (transcriptomics, proteomics, and phosphorylated proteomics). Monodansylcadaverine (MDC) staining and Western blotting analysis showed that SA promoted autophagy in by probably targeting the TOR signaling pathway. These observations suggest that SA has the potential to control late blight caused by .
致病卵菌可感染包括植物、动物和人类在内的多种生物体，导致全球农业、水产养殖和人类健康遭受巨大的经济损失。水杨酸（SA）作为一种内源性植物激素，被认为是植物免疫的诱导剂。在这里，我们以马铃薯晚疫病病原菌 为模型系统，揭示了 SA 对致病卵菌的抑制机制。本研究表明，SA 能显著抑制 的菌丝生长、孢子形成、游动孢子萌发和致病性。多组学分析（转录组学、蛋白质组学和磷酸化蛋白质组学）表明，抑制作用与 的自噬增强、翻译起始抑制和核糖体生物发生密切相关。单丹磺酰尸胺（MDC）染色和 Western blot 分析表明，SA 可能通过靶向 TOR 信号通路促进 的自噬。这些观察结果表明，SA 有可能控制 引起的晚疫病。
