Zamparelli R, Carelli G, Pennisi M A, Baruffi E, Schiavello R, Intonti M A, Intonti F
Scand J Thorac Cardiovasc Surg. 1986;20(3):241-5. doi: 10.3109/14017438609105932.
Zinc and copper changes were studied in plasma, whole blood, urine and myocardium in 15 patients undergoing valve replacement in hypothermic cardiopulmonary bypass with hemodilution. During the cardiopulmonary bypass, a fall in plasma copper and zinc concentration was related to hemodilution. The zinc concentration also decreased in whole blood, but remained unchanged intracellularly. The urinary concentration of both cations, but not the output, decreased at the end of the operation in relation to the baseline values. The myocardial copper and zinc concentrations increased during the aortic cross-clamping period. The possible causes and significance of these changes are considered.
对15例在低温体外循环加血液稀释下行瓣膜置换术的患者，研究了其血浆、全血、尿液和心肌中的锌和铜变化。在体外循环期间，血浆铜和锌浓度的下降与血液稀释有关。全血中的锌浓度也降低，但细胞内锌浓度保持不变。两种阳离子的尿浓度在手术结束时相对于基线值下降，但尿量未变。在主动脉交叉阻断期间，心肌铜和锌浓度升高。探讨了这些变化的可能原因及意义。
