Silverstone B A, Berson D, Grushka E, Kristol L, Hirsch I, Algur N
Department of Ophthalmology, Shaare Zedek Medical Center, Jerusalem, Israel.
Metab Pediatr Syst Ophthalmol (1985). 1985;8(2-3):61-8.
Several reports have appeared in the literature linking abnormalities in the Retinal Pigment Epithelium (RPE) related with changes in the metabolism of copper and zinc. It has not been yet elucidated if the changes in the metabolism of these metals are secondary to a progressive disease that affects the RPE, or the changes found in this retinal layer are a manifestation of a basic metabolic disease. In the present study a group of 22 diabetic patients with different degree of retinopathy was evaluated. Eleven of these patients underwent laser treatment, and blood and urine copper and zinc were assessed prior to the treatment and at intervals of one day, one week and one month post treatment. All these patients were compared with a control group. We found a rise in the mean concentration of copper and zinc in serum, and zinc in the urine, in those patients who underwent more than 600 laser applications. The significance of these findings and their relationship to the RPE is discussed.
文献中已有多篇报道将视网膜色素上皮（RPE）异常与铜和锌代谢变化联系起来。目前尚不清楚这些金属代谢的变化是继发于影响RPE的进行性疾病，还是在该视网膜层发现的变化是基础代谢疾病的一种表现。在本研究中，对一组22例不同程度视网膜病变的糖尿病患者进行了评估。其中11例患者接受了激光治疗，并在治疗前以及治疗后1天、1周和1个月时对血液和尿液中的铜和锌进行了评估。所有这些患者均与对照组进行了比较。我们发现，接受超过600次激光治疗的患者血清中铜和锌以及尿液中锌的平均浓度有所升高。本文讨论了这些发现的意义及其与RPE的关系。
