Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Biochim Biophys Acta Rev Cancer. 2024 Jan;1879(1):189051. doi: 10.1016/j.bbcan.2023.189051. Epub 2023 Dec 13.
This review delves into the most recent research on the metabolic adaptability of cancer cells and examines how their metabolic functions can impact their progression into metastatic forms. We emphasize the growing significance of lipid metabolism and dietary lipids within the tumor microenvironment, underscoring their influence on tumor progression. Additionally, we present an outline of the interplay between metabolic processes and the epigenome of cancer cells, underscoring the importance regarding the metastatic process. Lastly, we examine the potential of targeting metabolism as a therapeutic approach in combating cancer progression, shedding light on innovative drugs/targets currently undergoing preclinical evaluation.
本篇综述深入探讨了癌细胞代谢适应性的最新研究进展，并研究了它们的代谢功能如何影响其向转移性形式的进展。我们强调了肿瘤微环境中脂质代谢和膳食脂质的重要性，突出了它们对肿瘤进展的影响。此外，我们还概述了代谢过程与癌细胞表观基因组之间的相互作用，强调了它们在转移过程中的重要性。最后，我们研究了将代谢作为治疗方法靶向癌症进展的潜力，重点介绍了目前正在进行临床前评估的创新药物/靶点。
