新冠病毒感染两年后普通人群中持续存在的新冠后症状：系统评价和荟萃分析。

Persistence of post-COVID symptoms in the general population two years after SARS-CoV-2 infection: A systematic review and meta-analysis.

机构信息

Department of Physical Therapy, Occupational Therapy, Physical Medicine and Rehabilitation, Universidad Rey Juan Carlos, 28922 Madrid, Spain.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

出版信息

J Infect. 2024 Feb;88(2):77-88. doi: 10.1016/j.jinf.2023.12.004. Epub 2023 Dec 13.

DOI:10.1016/j.jinf.2023.12.004

PMID:38101521

Abstract

OBJECTIVE

This meta-analysis investigated the prevalence of post-COVID symptoms two-years after SARS-CoV-2 infection.

METHODS

Electronic literature searches on PubMed, MEDLINE, CINAHL, EMBASE, Web of Science databases, and on medRxiv/bioRxiv preprint servers were conducted up to October 1, 2023. Studies reporting data on post-COVID symptoms at two-years after infection were included. Methodological quality was assessed using the Newcastle-Ottawa Scale. Random-effects models were used for meta-analytical pooled prevalence of each symptom.

RESULTS

From 742 studies identified, twelve met inclusion criteria. The sample included 7912 COVID-19 survivors (50.7% female; age: 59.5, SD: 16.3). Post-COVID symptoms were assessed at a follow-up of 722.9 (SD: 51.5) days after. The overall methodological quality of studies was moderate (mean: 6/10, SD: 1.2 points). The most prevalent post-COVID symptoms two-years after SARS-CoV-2 infection were fatigue (28.0%, 95%CI 12.0-47.0), cognitive impairments (27.6%, 95%CI 12.6-45.8), and pain (8.4%, 95%CI 4.9-12.8). Psychological disturbances such as anxiety (13.4%, 95%CI 6.3-22.5) and depressive (18.0%, 95%CI 4.8-36.7) levels as well as sleep problems (20.9%, 95%CI 5.25-43.25) were also prevalent. Pooled data showed high heterogeneity (I ≥ 75%).

CONCLUSION

This meta-analysis shows the presence of post-COVID symptoms in 30% of patients two-years after COVID-19. Fatigue, cognitive disorders, and pain were the most prevalent post-COVID symptoms. Psychological disturbances as well as sleep problems were still present two-years after COVID-19.

摘要

目的

本荟萃分析旨在调查 SARS-CoV-2 感染后两年时出现的新冠后症状的流行情况。

方法

截至 2023 年 10 月 1 日，我们对 PubMed、MEDLINE、CINAHL、EMBASE、Web of Science 数据库以及 medRxiv/bioRxiv 预印本服务器进行了电子文献检索，纳入报告感染后两年时新冠后症状数据的研究。使用纽卡斯尔-渥太华量表评估方法学质量。使用随机效应模型对每种症状的荟萃分析汇总患病率进行分析。

结果

从 742 项研究中，有 12 项符合纳入标准。样本包括 7912 名新冠幸存者（50.7%为女性；年龄：59.5，SD：16.3）。新冠后症状是在感染后 722.9（SD：51.5）天进行评估的。研究的整体方法学质量为中等（平均：6/10，SD：1.2 分）。SARS-CoV-2 感染后两年时最常见的新冠后症状为疲劳（28.0%，95%CI 12.0-47.0）、认知障碍（27.6%，95%CI 12.6-45.8）和疼痛（8.4%，95%CI 4.9-12.8）。焦虑（13.4%，95%CI 6.3-22.5）和抑郁（18.0%，95%CI 4.8-36.7）等心理障碍以及睡眠问题（20.9%，95%CI 5.25-43.25）也很常见。汇总数据显示存在高度异质性（I ≥ 75%）。