Raafat I I, El Guindy N, Shahin R M H, Samy L A, El Refai R M
Department of Clinical Pathology, Kasr Al Ainy Hospital, Cairo University, Cairo, Egypt.
Department of Rheumatology and Rehabilitation, Kasr Al Ainy Hospital, Cairo University, Cairo, Egypt.
Z Rheumatol. 2018 Jun;77(5):416-420. doi: 10.1007/s00393-017-0283-7.
Toll-like receptors (TLRs) are a family of pattern-recognition receptors which play a role in eliciting innate/adaptive immune responses and developing chronic inflammation. So, the aim of this study was to analyze the effect of TLR7 gene single nucleotide polymorphisms (SNPs) rs3853839 and rs179019 on systemic lupus erythematosus (SLE) susceptibility and to assess their relations with various clinical and laboratory data of the patients.
This is a case-control study including 50 SLE female patients and 50 healthy controls. TLR7 rs3853839 and rs179019 genotyping was performed using real-time polymerase chain reaction (PCR) TaqMan-based allelic discrimination assay.
Regarding rs3853839, there was a statistically significant difference in the distribution of the genotypes between SLE patients and the control group in our study (P = 0.009). A significant association was detected between TLR7 genotypes (rs385389) and lupus nephritis (p = 0.021). Regarding rs179019, there was no statistically significant difference in the distribution of the genotypes between SLE patients and the control group in our study (P = 0.271) CONCLUSION: This study revealed the plausible role of TLR7 rs3853839 SNP in SLE in Egyptian women.
Toll样受体（TLRs）是一类模式识别受体，在引发先天性/适应性免疫反应和发展慢性炎症中发挥作用。因此，本研究的目的是分析TLR7基因单核苷酸多态性（SNPs）rs3853839和rs179019对系统性红斑狼疮（SLE）易感性的影响，并评估它们与患者各种临床和实验室数据的关系。
这是一项病例对照研究，包括50名SLE女性患者和50名健康对照。使用基于实时聚合酶链反应（PCR）TaqMan的等位基因鉴别分析进行TLR7 rs3853839和rs179019基因分型。
关于rs3853839，在我们的研究中，SLE患者和对照组之间基因型分布存在统计学显著差异（P = 0.009）。在TLR7基因型（rs385389）与狼疮性肾炎之间检测到显著关联（p = 0.021）。关于rs179019，在我们的研究中，SLE患者和对照组之间基因型分布没有统计学显著差异（P = 0.271）。结论：本研究揭示了TLR7 rs3853839 SNP在埃及女性SLE中的可能作用。
