Hirose M, Hagiwara A, Inoue K, Sakata T, Ito N, Kaneko H, Yoshitake A, Miyamoto J
Toxicology. 1987 Feb;43(2):139-47. doi: 10.1016/0300-483x(87)90004-7.
The mechanism of the carcinogenic or toxic action of BHA on rat forestomach was examined by studies on the excretion and tissue distribution of radioactivity in F344 male rats given tert-butyl- or methoxy-labelled 3-BHA orally. Within 2 days after a single oral dose of labelled BHA at 1 g/kg body wt, 87-96% of the 14C was excreted, mainly in the urine with smaller amounts in the feces and expired air. More 14C was found in the tissues of rats given the methoxy-labelled compounds. The distributions of 14C in the forestomach and the glandular stomach were similar. At 168 h after treatment, more 14C was found in the forestomach of rats given 2-BHA than in that of rats given 3-BHA. These results indicate that excretion of BHA is rapid, that 4-O-methyl demethylation may take place readily and that demethylated methyl group may become distributed non-specifically in tissues. The carcinogenic or toxic action of BHA on the forestomach does not seem to be due accumulation of BHA in the forestomach.
通过对口服叔丁基或甲氧基标记的3 - BHA的F344雄性大鼠放射性的排泄和组织分布研究，考察了丁基羟基茴香醚（BHA）对大鼠前胃的致癌或毒性作用机制。以1 g/kg体重单次口服给予标记的BHA后2天内，87 - 96%的14C被排泄，主要经尿液排出，少量经粪便和呼出气体排出。给予甲氧基标记化合物的大鼠组织中发现更多的14C。14C在前胃和腺胃中的分布相似。处理后168小时，给予2 - BHA的大鼠前胃中发现的14C比给予3 - BHA的大鼠更多。这些结果表明，BHA排泄迅速，4 - O - 甲基去甲基化可能容易发生，且去甲基化的甲基可能非特异性地分布于组织中。BHA对前胃的致癌或毒性作用似乎并非由于BHA在前胃中的蓄积。
